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Substance Name: Forigerimod [USAN:INN]
RN: 497156-60-2
UNII: 1JRB6UKG4Q
InChIKey: LSLBZWAEEUGETG-GGVFYUGVSA-N

Note

  • Synthetic peptide, sequence 131-151 of the U1-70K protein phosphorylated at Ser140, which is recognized by lupus CD4 T cells for the treatment of patients with systemic lupus erythematosus.

Molecular Formula

  • C117-H181-N34-O32-P-S

Molecular Weight

  • 2638.9629
 

Classification Code

  • Treatment of Systemic Lupus Erythematosus (SLE)
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Names and Synonyms

Name of Substance

  • Forigerimod [USAN:INN]
  • Spliceosomal peptide P140

Synonyms

  • CEP 33457
  • CEP-33457
  • Forigerimod
  • IPP 201101
  • Lupuzor
  • O(sup 3,140)-Phosphono(human U1 small nuclear ribonucleoprotein 70 kDa (snRNP70))-(131- 151)-peptide
  • P140 peptide
  • UNII-1JRB6UKG4Q

Systematic Name

  • L-Tyrosine, L-arginyl-L-isoleucyl-L-histidyl-L-methionyl-L-valyl-L-tyrosyl-L-seryl-L-lysyl-L- arginyl-O-phosphono-L-serylglycyl-L-lysyl-L-prolyl-L-arginylglycyl-L-tyrosyl-L-alanyl-L- phenylalanyl-L-isoleucyl-L-alpha-glutamyl-

Registry Numbers

CAS Registry Number

  • 497156-60-2

FDA UNII

  • 1JRB6UKG4Q

Other Registry Number

  • 1039726-86-7

System Generated Number

  • 0497156602

Structure Descriptors

InChI

1S/C117H181N34O32PS/c1-9-64(5)94(148-99(163)75(120)24-18-47-128-115(121)122)112(176)144-85(56-71-57-127-62-132-71)106(170)139-80(44-51-185-8)103(167)147-93(63(3)4)110(174)143-83(54-69-32-38-73(154)39-33-69)105(169)146-87(60-152)108(172)138-78(25-14-16-45-118)101(165)137-76(27-19-48-129-116(123)124)96(160)97(161)88(150-184(180,181)182)61-183-133-59-91(157)135-81(26-15-17-46-119)113(177)151-50-21-29-89(151)109(173)140-77(28-20-49-130-117(125)126)100(164)131-58-90(156)136-82(53-68-30-36-72(153)37-31-68)104(168)134-66(7)98(162)142-84(52-67-22-12-11-13-23-67)107(171)149-95(65(6)10-2)111(175)141-79(42-43-92(158)159)102(166)145-86(114(178)179)55-70-34-40-74(155)41-35-70/h11-13,22-23,30-41,57,62-66,75-89,93-95,133,152-155H,9-10,14-21,24-29,42-56,58-61,118-120H2,1-8H3,(H,127,132)(H,131,164)(H,134,168)(H,135,157)(H,136,156)(H,137,165)(H,138,172)(H,139,170)(H,140,173)(H,141,175)(H,142,162)(H,143,174)(H,144,176)(H,145,166)(H,146,169)(H,147,167)(H,148,163)(H,149,171)(H,158,159)(H,178,179)(H4,121,122,128)(H4,123,124,129)(H4,125,126,130)(H3,150,180,181,182)/t64-,65-,66-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,93-,94-,95-/m0/s1

InChIKey

LSLBZWAEEUGETG-GGVFYUGVSA-N

Smiles

P(=O)(O)(O)N[C@H](C(=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)Cc1[nH]cnc1)CCSC)[C@@H](C)C)Cc1ccc(cc1)O)CO)CCCCN)CCCNC(=N)N)CONCC(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc2ccc(cc2)O)CCC(=O)O)[C@@H](C)CC)Cc2ccccc2)Cc2ccc(cc2)O)CCCNC(=N)N)CCC1)CCCCN