Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Dobutamine hydrochloride [USAN:USP:BAN:JAN]
RN: 49745-95-1
UNII: 0WR771DJXV
InChIKey: BQKADKWNRWCIJL-UHFFFAOYSA-N

Note

  • A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Molecular Formula

  • C18-H23-N-O3.x-Cl-H

Molecular Weight

  • 337.8446
 

Classification Code

  • Cardiotonic
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Dobutamine hydrochloride [USAN:USP:BAN:JAN]

Synonyms

  • (+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol hydrochloride
  • 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, hydrochloride, (+-)-
  • DL-Dobutamine hydrochloride
  • Dobutamina clorhidrato [Spanish]
  • Dobutamine HCl
  • Dobutamine hydrochloride
  • Dobutamine hydrochloride in dextrose 5%
  • Dobutamine hydrochloride in dextrose 5% in plastic container
  • Dobutrex
  • EINECS 256-464-1
  • Inotrex
  • LY 46236
  • NSC 299583
  • S-1000
  • UNII-0WR771DJXV

Systematic Names

  • 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, hydrochloride
  • 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, hydrochloride, (+-)-
  • 4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatecholhydrochloride

Registry Numbers

CAS Registry Number

  • 49745-95-1

FDA UNII

  • 0WR771DJXV

Other Registry Number

  • 52663-81-7

System Generated Number

  • 0049745951

Molecular Formulas

Molecular Formula

  • C18-H23-N-O3.x-Cl-H

Molecular Formula Fragments

  • C18-H23-N-O3
  • Cl-H

Structure Descriptors

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChIKey

BQKADKWNRWCIJL-UHFFFAOYSA-N

Smiles

c1(c(cc(cc1)CCNC(CCc1ccc(cc1)O)C)O)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral > 40mg/kg (40mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Medicamentos de Actualidad. Vol. 14, Pg. 431, 1978.
cat LDLo intravenous > 40mg/kg (40mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 109, 1977.
dog LD50 oral > 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Medicamentos de Actualidad. Vol. 14, Pg. 431, 1978.
dog LDLo intravenous > 40mg/kg (40mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 109, 1977.
man LDLo intravenous 5ug/kg/1M-C (0.005mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Medicine. Vol. 108, Pg. 352, 2000.
mouse LD50 intraperitoneal 243mg/kg (243mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 627, 1979.
mouse LD50 intravenous 34300ug/kg (34.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 627, 1979.
mouse LD50 oral 1324mg/kg (1324mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 subcutaneous 341mg/kg (341mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 627, 1979.
rat LD50 intraperitoneal 260mg/kg (260mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 intravenous 59600ug/kg (59.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 627, 1979.
rat LD50 oral 2296mg/kg (2296mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 subcutaneous 368mg/kg (368mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.