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Substance Name: Azaclorzine hydrochloride [USAN]
RN: 49780-10-1
UNII: 7531I37BK3
InChIKey: UERHIZBSLAGDLU-UHFFFAOYSA-N

Note

  • Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.

Molecular Formula

  • C22-H24-Cl-N3-O-S.2Cl-H

Molecular Weight

  • 486.8924
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Vasodilator (Coronary)
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Azaclorzine hydrochloride [USAN]
  • Nonachlazine

MeSH Heading

  • Nonachlazine

Synonyms

  • 10'-(beta-(1,4-Diazabicyclo(4.3.0)nonanyl-4)-propionyl)-2'-chlorophenthiazin dichloride
  • 10H-Phenothiazine, 2-chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-1-oxopropyl)-, dihydrochloride
  • 2-Chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-propionyl)phenothiazine dihydrochloride
  • AY 25329
  • AY-25,329
  • Azaclorzine HCl
  • Azaclorzine hydrochloride
  • Nonachlazine
  • UNII-7531I37BK3

Systematic Names

  • 10H-Phenothiazine, 2-chloro-10-(3-(1,4-diazabicyclo(4.3.0)nonanyl)propionyl)-, dihydrochloride
  • 10H-Phenothiazine, 2-chloro-10-(3-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-1-oxopropyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 49780-10-1

FDA UNII

  • 7531I37BK3

System Generated Number

  • 0049780101

Molecular Formulas

Molecular Formula

  • C22-H24-Cl-N3-O-S.2Cl-H

Molecular Formula Fragments

  • C22-H24-Cl-N3-O-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H24ClN3OS.2ClH/c23-16-7-8-21-19(14-16)26(18-5-1-2-6-20(18)28-21)22(27)9-11-24-12-13-25-10-3-4-17(25)15-24;;/h1-2,5-8,14,17H,3-4,9-13,15H2;2*1H

InChIKey

UERHIZBSLAGDLU-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)N(c3cc(ccc3S2)Cl)C(=O)CCN4CCN5CCCC5C4.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 55mg/kg (55mg/kg)   Farmakologiya i Toksikologiya Vol. 38, Pg. 732, 1975.
mouse LD50 oral 160mg/kg (160mg/kg)   Farmakologiya i Toksikologiya Vol. 42, Pg. 243, 1979.
mouse LD50 subcutaneous 210mg/kg (210mg/kg)   Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.