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Substance Name: Supidimide [INN]
RN: 49785-74-2
UNII: L2GWR3US1G
InChIKey: QQWLXNMPPFCVCD-UHFFFAOYSA-N

Note

  • Non-teratogenic analog of thalidomide; has mild tranquilizing action.

Molecular Formula

  • C12-H12-N2-O4-S

Molecular Weight

  • 280.303
 
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Names and Synonyms

Name of Substance

  • Supidimide
  • Supidimide [INN]

Synonyms

  • 2,3-Dihydro-2-(2-oxo-3-piperidyl)-1,2-benzisothiazol-3-on 1,1-dioxid
  • 2-(2-Oxo-3-piperidyl)-1,2-benzisothiazolin-3-one 1,1-dioxide
  • 3-(2,3-Dihydro-1,1-dioxido-3-oxo-1,2-benzisothiazol-2-yl)-2-oxopiperidine
  • CG 3033
  • EINECS 256-490-3
  • EM 87
  • Supidimida
  • Supidimida [INN-Spanish]
  • Supidimide
  • Supidimidum
  • Supidimidum [INN-Latin]
  • UNII-L2GWR3US1G

Systematic Names

  • 1,2-Benzisothiazolin-3-one, 2-(2-oxo-3-piperidyl)-, 1,1-dioxide
  • Supidimide

Registry Numbers

CAS Registry Number

  • 49785-74-2

FDA UNII

  • L2GWR3US1G

System Generated Number

  • 0049785742

Structure Descriptors

InChI

1S/C12H12N2O4S/c15-11-9(5-3-7-13-11)14-12(16)8-4-1-2-6-10(8)19(14,17)18/h1-2,4,6,9H,3,5,7H2,(H,13,15)

InChIKey

QQWLXNMPPFCVCD-UHFFFAOYSA-N

Smiles

N1([C@@H]2C(NCCC2)=O)C(c2ccccc2S1(=O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3250mg/kg (3250mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 941, 1981.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 941, 1981.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4067985,