Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Tobramycin sulfate [USP]
RN: 49842-07-1
UNII: HJT0RXD7JK
InChIKey: NZKFUBQRAWPZJP-BXKLGIMVSA-N

Note

  • An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

Molecular Formula

  • C18-H37-N5-O9.5/2H2-O4-S

Molecular Weight

  • 1425.4216
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
  • Human Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Tobramycin sulfate [USP]

Synonyms

  • Distobram
  • EINECS 256-499-2
  • Gernebcin
  • Nebcin
  • Nebicina
  • Obracine
  • Tenemicin
  • Tobi
  • Tobra
  • Tobramycin (pharmacy bulk)
  • Tobramycin sulfate
  • Tobramycin sulfate in sodium chloride 0.9% in plastic container
  • Tobramycin sulphate
  • UNII-HJT0RXD7JK

Systematic Names

  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-, sulfate (2:5)(salt)
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1.fwdarw.4))-2-deoxy-, sulfate (2:5) (salt)
  • Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-, D-, sulfate (salt)
  • Tobramycin sulphate

Superlist Name

  • Tobramycin sulfate

Mixture Name

  • T-Pred

Registry Numbers

CAS Registry Number

  • 49842-07-1

FDA UNII

  • HJT0RXD7JK

Other Registry Number

  • 79645-27-5

Related Registry Number

  • 32986-56-4 (Parent)

System Generated Number

  • 0049842071

Molecular Formulas

Molecular Formula

  • C18-H37-N5-O9.5/2H2-O4-S

Molecular Formula Fragments

  • C18-H37-N5-O9
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C18H37N5O9.5H2O4S/c2*19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;5*1-5(2,3)4/h2*5-18,24-28H,1-4,19-23H2;5*(H2,1,2,3,4)/t2*5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;;;;;/m00...../s1

InChIKey

NZKFUBQRAWPZJP-BXKLGIMVSA-N

Smiles

C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N.C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 262mg/kg (262mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Antibiotiki. Vol. 24, Pg. 60, 1979.
mouse LD50 intravenous 77mg/kg (77mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotiki. Vol. 24, Pg. 60, 1979.
mouse LD50 oral > 10500mg/kg (10500mg/kg)   Antibiotiki. Vol. 24, Pg. 60, 1979.
mouse LD50 subcutaneous 560mg/kg (560mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Antibiotiki. Vol. 24, Pg. 60, 1979.
rat LD50 intravenous 126mg/kg (126mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotiki. Vol. 24, Pg. 60, 1979.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotiki. Vol. 24, Pg. 60, 1979.
women LDLo intravenous 15mg/kg/5D-I (15mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: WAKEFULNESS
JAMA, Journal of the American Medical Association. Vol. 247, Pg. 1319, 1982.