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Substance Name: Noxiptilin hydrochloride
RN: 4985-15-3
UNII: PNW59W2B94
InChIKey: JIKBYFBMUAUPJS-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H22-N2-O.Cl-H

Molecular Weight

  • 330.8567
 
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Names and Synonyms

Name of Substance

  • Noxiptilin hydrochloride

Synonyms

  • 5-(Dimethylaminoaethyl-oxyimino)-5H-dibenzo(a,d)cyclohepta-1,4-dien hydrochlorid
  • 5-(Dimethylaminoaethyl-oxyimino)-5H-dibenzo(a,d)cyclohepta-1,4-dien hydrochlorid [German]
  • 5-(Dimethylaminooxyimino)-5H-dibenzo(a,b)cyclohepta-1,4-diene hydrochloride
  • 5-(Dimetilaminoetiloximino-5H-dibenzo(a,d)cicloepta-1,4-diene) cloridrato
  • 5-(Dimetilaminoetiloximino-5H-dibenzo(a,d)cicloepta-1,4-diene) cloridrato [Italian]
  • 5-Dimethylaminoethyloxyimino-5H-dibenzo(a,d)cyclohepta-1,4-diene hydrochloride
  • Agedal
  • BAY 1521
  • EINECS 225-638-9
  • Elronon
  • Nogedal
  • Noxiptilin HCl
  • Noxiptilin hydrochlorid
  • Noxiptilin hydrochlorid [German]
  • Noxiptiline hydrochloride
  • Noxiptyline hydrochloride
  • UNII-PNW59W2B94

Systematic Names

  • 10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-one O-(2-(dimethylamino)ethyl)oxime monohydrochloride
  • 5H-Dibenzo(a,d)cyclohepten-5-one, 10,11-dihydro-, O-(2-(dimethylamino)ethyl)oxime, hydrochloride

Registry Numbers

CAS Registry Number

  • 4985-15-3

FDA UNII

  • PNW59W2B94

Related Registry Number

  • 3362-45-6 (Parent)

System Generated Number

  • 0004985153

Molecular Formulas

Molecular Formula

  • C19-H22-N2-O.Cl-H

Molecular Formula Fragments

  • C19-H22-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H22N2O.ClH/c1-21(2)13-14-22-20-19-17-9-5-3-7-15(17)11-12-16-8-4-6-10-18(16)19;/h3-10H,11-14H2,1-2H3;1H

InChIKey

JIKBYFBMUAUPJS-UHFFFAOYSA-N

Smiles

C[NH+](C)CCON=C1c2ccccc2CCc3c1cccc3.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
cat LD50 subcutaneous 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
dog LD50 oral 800mg/kg (800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
dog LD50 subcutaneous 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
mouse LD50 intramuscular 144mg/kg (144mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intraperitoneal 93mg/kg (93mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intravenous 21300ug/kg (21.3mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1897, 1972.
mouse LD50 oral 275mg/kg (275mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1897, 1972.
mouse LD50 subcutaneous 212mg/kg (212mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1897, 1972.
rabbit LD50 oral 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
rabbit LD50 subcutaneous 50mg/kg (50mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 846, 1969.
rat LD50 intramuscular 209mg/kg (209mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intraperitoneal 149mg/kg (149mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intravenous 12mg/kg (12mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1897, 1972.
rat LD50 oral 607mg/kg (607mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 subcutaneous 985mg/kg (985mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 84, 1972.