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Substance Name: Guanidine hydrochloride
RN: 50-01-1
UNII: 3YQC9ZY4YB
InChIKey: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Note

  • A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Molecular Formula

  • C-H5-N3.Cl-H

Molecular Weight

  • 95.5324
 

Classification Codes

  • Mutation Data
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Guanidine hydrochloride

Synonyms

  • AI3-19014
  • Aminoformamidine hydrochloride
  • Aminomethanamidine hydrochloride
  • Carbamidine hydrochloride
  • CCRIS 8910
  • EC 200-002-3
  • EINECS 200-002-3
  • Guanidine chloride
  • Guanidine hydrochloride
  • Guanidine monohydrochloride
  • Guanidinium chloride
  • Guanidinium hydrochloride
  • Iminourea hydrochloride
  • UNII-3YQC9ZY4YB
  • USAF EK-749

Systematic Names

  • Guanidine, hydrochloride (1:1)
  • Guanidine, monohydrochloride
  • Guanidinium chloride

Registry Numbers

CAS Registry Number

  • 50-01-1

FDA UNII

  • 3YQC9ZY4YB

Other Registry Numbers

  • 106946-18-3
  • 1340579-42-1
  • 139693-44-0
  • 14317-32-9
  • 143504-22-7
  • 15827-40-4
  • 420-13-3
  • 87667-20-7
  • 915070-50-7
  • 94369-44-5

Related Registry Number

  • 113-00-8 (Parent)

System Generated Number

  • 0000050011

Molecular Formulas

Molecular Formula

  • C-H5-N3.Cl-H

Molecular Formula Fragments

  • C-H5-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChIKey

PJJJBBJSCAKJQF-UHFFFAOYSA-N

Smiles

C(=N)(N)N.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 200mg/kg (200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
guinea pig LDLo intraarterial 500mg/kg (500mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 500mg/kg (500mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo subcutaneous 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
mammal (species unspecified) LDLo oral 300mg/kg (300mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 571mg/kg (571mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: IRRITABILITY
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993.
rabbit LD skin > 2gm/kg (2000mg/kg)   Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993.
rat LD50 oral 475mg/kg (475mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
National Technical Information Service. Vol. AD-A165-747,
rat LDLo subcutaneous 404mg/kg (404mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 182.3 deg C   EXP
log P (octanol-water) -3.560 (none)   EST
Atmospheric OH Rate Constant 2.10E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.