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Substance Name: Hydrocortisone acetate [USP:BAN:JAN]
RN: 50-03-3
UNII: 3X7931PO74
InChIKey: ALEXXDVDDISNDU-JZYPGELDSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C23-H32-O6

Molecular Weight

  • 404.4998
 
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Names and Synonyms

Name of Substance

  • Hydrocortisone acetate [USP:BAN:JAN]

Synonyms

  • 11-beta,17-alpha-Dihydroxy-21-acetoxypregesterone
  • 17-alpha-Hydroxycorticosterone acetate
  • 17-Hydroxycorticosterone-21-acetate
  • 21-Acetoxy-11-beta,17-alpha-dihydroxypregn-4-ene-3,20-dione
  • Abbocort
  • Acepolcort-H
  • Acetate-AS
  • Aceto-cort
  • AI3-26389
  • Ala scalp
  • Alfacorton
  • Allocort
  • Anusol-HC
  • Bambicort
  • Berlison
  • Berlison F
  • Biocortar
  • Carmol HC
  • Chemysone
  • Collusul-HC
  • Compound F acetate
  • Cortacream
  • Cortaid
  • Cortef acetate
  • Cortell
  • Cortes
  • Corti
  • Corti Selbe
  • Cortic
  • Corticosterone, 17-hydroxy-, 21-acetate
  • Cortiderm
  • Cortidro
  • Cortifoam
  • Cortiform
  • Cortimycine
  • Cortioftal
  • Cortisol 21-acetate
  • Cortisol acetate
  • Cortril
  • Cortril acetate
  • Cortril acetate-AS
  • Crema transcutan
  • Derminovag
  • Dermosa hidrocortisona
  • Dricort
  • Ebenol
  • EC 200-004-4
  • Efzem
  • EINECS 200-004-4
  • Ekzemsalbe F
  • Eye-Cort
  • Fenitral
  • Fernisone
  • Glycocortison
  • HA
  • Hemsol-HC
  • Hidrocortisona
  • Hipokort
  • Hycor Eye Oitment
  • Hycortole acetate
  • Hyderm
  • Hydrin-2
  • Hydriocort von ct
  • Hydrison
  • Hydro-Adreson
  • Hydro-Adreson [inj.]
  • Hydrocortisat
  • Hydrocortison
  • Hydrocortison Streuli
  • Hydrocortisone 21-acetate
  • Hydrocortisone acetate
  • Hydrocortisonum
  • Hydrocortistab
  • Hydrocortone
  • Hydrocortone acetate
  • Hydrosone
  • Hydrosone-A
  • Hydroxycorticosterone acetate
  • Hysone-A
  • Idrocort
  • Idrocortigamma
  • Idrocortisone Acetano
  • Iracetisone
  • Isopto-hydrocortisone
  • Korti
  • Lanacort
  • Latimit
  • Lenirit
  • Medithane
  • Micort-HC
  • Mysone
  • NSC 741
  • Oft Cusi Hidrocortisona
  • Ophticor
  • Orabase HCA
  • Pabracort
  • Pannocort
  • Paro
  • Posterine Corte
  • Pregn-4-ene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-acetate
  • Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate
  • Pregn-4-ene-3,20-dione, 21-(acetoxy)-11,17-dihydroxy-, (11-beta)-
  • Proctocort
  • Resicort
  • Sagittacortin
  • Sanadermil
  • Siguent Hycor
  • Sintotrat
  • Soenol Hydrocortison
  • Squibb-HC
  • Supralef
  • U-Cort
  • UNII-3X7931PO74
  • Urecortyn
  • Velopural
  • Wycort

Systematic Names

  • Cortisol, 21-acetate
  • Hydrocortisone 21-acetate
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-

Mixture Names

  • Bacicoline
  • Chloromycetin Hydrocortisone Ophthalmic
  • Clear-Aid
  • Coly-Mycin S Otic
  • Corticaine Cream
  • Cortifoam
  • Cortisporin Cream
  • Epifoam
  • Lidaform-HC
  • Lidamantle-HC
  • Mantadil
  • Neo-Cortef
  • Neobacimyx (Veterinary)
  • Ophthocort
  • Proctocream-HC
  • Proctofoam-HC
  • Protef

Registry Numbers

CAS Registry Number

  • 50-03-3

FDA UNII

  • 3X7931PO74

Other Registry Numbers

  • 42016-02-4
  • 60620-33-9

System Generated Number

  • 0000050033

Structure Descriptors

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChIKey

ALEXXDVDDISNDU-JZYPGELDSA-N

Smiles

CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2300mg/kg (2300mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 subcutaneous 45050ug/kg (45.05mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LDLo subcutaneous 250mg/kg (250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 223 dec deg C   EXP
log P (octanol-water) 2.19 (none)   EXP
Water Solubility 14.1 mg/L 25 EXP
Vapor Pressure 2.56E-13 mm Hg 25 EST
Henry's Law Constant 6.24E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.13E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.