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Substance Name: Hydrocortisone [USP:INN:BAN:JAN]
RN: 50-23-7
UNII: WI4X0X7BPJ
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
Note
- The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Molecular Formula
- C21-H30-O5
Molecular Weight
- 362.463
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Inflammatory Agents
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Glucocorticoid
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Hydrocortisone
- Hydrocortisone [USP:INN:BAN:JAN]
MeSH Heading
- Hydrocortisone
Synonyms
- 11-beta-Hydrocortisone
- 11-beta-Hydroxycortisone
- 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
- 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
- 11beta-Hydroxycortisone
- 17-Hydroxycorticosterone
- 17alpha-Hydroxycorticosterone
- 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
- Acticort
- Aeroseb-HC
- AI3-25006
- Ala-Cort
- Ala-Scalp
- Alacort
- Algicirtis
- Amberin
- Anflam
- Anti-inflammatory hormone
- Anucort
- Anucort-HC
- Anusol HC
- Aquacort
- Aquanil HC
- Balneol-HC
- Barseb HC
- Basan-Corti
- Beta-HC
- CCRIS 5854
- Cetacort
- Clear aid
- Cleiton
- Cobadex
- Colocort
- Compound F (kendall)
- Cort-Dome
- Cortanal
- Cortef
- Cortef
- Cortenema
- Cortesal
- Corticreme
- Cortifan
- Cortiment
- Cortisol
- Cortisol alcohol
- Cortisolonum
- Cortisporin Otico
- Cortispray
- Cortolotion
- Cortonema
- Cortoxide
- Cortril
- Cremesone
- Cremicort-H
- Cutisol
- Delacort
- Derm-Aid
- Dermacort
- Dermaspray
- Dermil
- Dermocortal
- Dermolate
- Dihydrocostisone
- Dioderm
- Dome-cort
- Domolene-HC
- EC 200-020-1
- Efcorbin
- Efcortelan
- EINECS 200-020-1
- Eldecort
- Eldercort
- Epicort
- Epiderm H
- Esiderm H
- Evacort
- Ficortril
- Flexicort
- Foille Insetti
- Genacort
- Genacort (lotion)
- Glycort
- Gyno-Cortisone
- H-Cort
- HC
- HC #1
- HC #4
- HC (hydrocortisone)
- Heb Cort
- Heb-Cort
- HI-Cor
- Hidalone
- Hidro-colisona
- Hidrocortisona
- Hidrocortisona [INN-Spanish]
- HSDB 3339
- Hycort
- Hycortol
- Hycortole
- Hydrasson
- Hydro-Adreson
- Hydro-Colisona
- Hydro-RX
- Hydrocorticosterone
- Hydrocortisone
- Hydrocortisone alcohol
- Hydrocortisone free alcohol
- Hydrocortisone in absorbase
- Hydrocortisone, topical
- Hydrocortisonum
- Hydrocortisonum [INN-Latin]
- Hydrocortisyl
- Hydrocortone
- Hydroxycortisone
- Hytisone
- Hytone
- Hytone lotion
- Idrocortisone
- Idrocortisone [DCIT]
- Incortin-H
- Incortin-hydrogen
- Kendall's compound F
- Komed HC
- Kyypakkaus
- Lacticare-HC
- Lactisona
- Lubricort
- Maintasone
- Meusicort
- Mildison
- Milliderm
- Neosporin-H Ear
- Nogenic HC
- NSC 10483
- Nutracort
- Optef
- Otosone-F
- Penecort
- Permicort
- Polcort H
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
- Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
- Preparation H Hydrocortisone Cream
- Prevex HC
- Proctocort
- Proctofoam
- Proctosol-HC
- Proctozone HC
- Rectasol-HC
- Rectoid
- Reichstein's substance M
- Remederm HC
- Sanatison
- Scalp-Cort
- Scalpicin Capilar
- Schericur
- Scheroson F
- Sigmacort
- Signef
- Stie-Cort
- Stiefcorcil
- Synacort
- Systral Hydrocort
- Tarcortin
- Texacort
- Texacort lotion 25
- Timocort
- Transderma H
- Traumaide
- Uniderm
- UNII-WI4X0X7BPJ
Systematic Names
- Cortisol
- Hydrocortisone
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
Mixture Names
- Cor-Tar-Quin
- Cort-Quin
- Cortisporin
- Drotic
- Neo-Cort-Dome
- Nystaform-HC
- Otalgine
- Otic-Neo-Cort-Dome
- Otobiotic
- Otocort
- Pediotic Suspension
- Racet
- Vioform-Hydrocortisone
- Vosol HC
- Vytone
- Xerese
Registry Numbers
CAS Registry Number
- 50-23-7
FDA UNII
- WI4X0X7BPJ
Other Registry Numbers
- 1050676-88-4
- 1436392-18-5
- 8056-08-4
- 80562-38-5
- 8063-42-1
System Generated Number
- 0000050237
Structure Descriptors
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1InChIKey
JYGXADMDTFJGBT-VWUMJDOOSA-NSmiles
C[C@]12CCC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 400mg/kg/10D- (400mg/kg) | BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Psychopharmacology Vol. 145, Pg. 260, 1999. |
| mouse | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990. | |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971. | |
| rat | LD50 | subcutaneous | 449mg/kg (449mg/kg) | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 220 | deg C | EXP | |
| log P (octanol-water) | 1.61 | (none) | EXP | |
| Water Solubility | 320 | mg/L | 25 | EXP |
| Vapor Pressure | 1.35E-13 | mm Hg | 25 | EST |
| Henry's Law Constant | 5.77E-08 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.14E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.