Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Hydrocortisone [USP:INN:BAN:JAN]
RN: 50-23-7
UNII: WI4X0X7BPJ
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N

Note

  • The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Molecular Formula

  • C21-H30-O5

Molecular Weight

  • 362.463
 

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Hydrocortisone
  • Hydrocortisone [USP:INN:BAN:JAN]

MeSH Heading

  • Hydrocortisone

Synonyms

  • 11-beta-Hydrocortisone
  • 11-beta-Hydroxycortisone
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
  • 11beta-Hydroxycortisone
  • 17-Hydroxycorticosterone
  • 17alpha-Hydroxycorticosterone
  • 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
  • Acticort
  • Aeroseb-HC
  • AI3-25006
  • Ala-Cort
  • Ala-Scalp
  • Alacort
  • Algicirtis
  • Amberin
  • Anflam
  • Anti-inflammatory hormone
  • Anucort
  • Anucort-HC
  • Anusol HC
  • Aquacort
  • Aquanil HC
  • Balneol-HC
  • Barseb HC
  • Basan-Corti
  • Beta-HC
  • CCRIS 5854
  • Cetacort
  • Clear aid
  • Cleiton
  • Cobadex
  • Colocort
  • Compound F (kendall)
  • Cort-Dome
  • Cortanal
  • Cortef
  • Cortenema
  • Cortesal
  • Corticreme
  • Cortifan
  • Cortiment
  • Cortisol
  • Cortisol alcohol
  • Cortisolonum
  • Cortisporin Otico
  • Cortispray
  • Cortolotion
  • Cortonema
  • Cortoxide
  • Cortril
  • Cremesone
  • Cremicort-H
  • Cutisol
  • Delacort
  • Derm-Aid
  • Dermacort
  • Dermaspray
  • Dermil
  • Dermocortal
  • Dermolate
  • Dihydrocostisone
  • Dioderm
  • Dome-cort
  • Domolene-HC
  • EC 200-020-1
  • Efcorbin
  • Efcortelan
  • EINECS 200-020-1
  • Eldecort
  • Eldercort
  • Epicort
  • Epiderm H
  • Esiderm H
  • Evacort
  • Ficortril
  • Flexicort
  • Foille Insetti
  • Genacort
  • Genacort (lotion)
  • Glycort
  • Gyno-Cortisone
  • H-Cort
  • HC
  • HC #1
  • HC #4
  • HC (hydrocortisone)
  • Heb Cort
  • Heb-Cort
  • HI-Cor
  • Hidalone
  • Hidro-colisona
  • Hidrocortisona
  • Hidrocortisona [INN-Spanish]
  • HSDB 3339
  • Hycort
  • Hycortol
  • Hycortole
  • Hydrasson
  • Hydro-Adreson
  • Hydro-Colisona
  • Hydro-RX
  • Hydrocorticosterone
  • Hydrocortisone
  • Hydrocortisone alcohol
  • Hydrocortisone free alcohol
  • Hydrocortisone in absorbase
  • Hydrocortisonum
  • Hydrocortisonum [INN-Latin]
  • Hydrocortisyl
  • Hydrocortone
  • Hydroxycortisone
  • Hytisone
  • Hytone
  • Hytone lotion
  • Idrocortisone
  • Idrocortisone [DCIT]
  • Incortin-H
  • Incortin-hydrogen
  • Kendall's compound F
  • Komed HC
  • Kyypakkaus
  • Lacticare-HC
  • Lactisona
  • Lubricort
  • Maintasone
  • Meusicort
  • Mildison
  • Milliderm
  • Neosporin-H Ear
  • Nogenic HC
  • NSC 10483
  • Nutracort
  • Optef
  • Otosone-F
  • Penecort
  • Permicort
  • Polcort H
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
  • Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
  • Preparation H Hydrocortisone Cream
  • Prevex HC
  • Proctocort
  • Proctofoam
  • Proctosol-HC
  • Proctozone HC
  • Rectasol-HC
  • Rectoid
  • Reichstein's substance M
  • Remederm HC
  • Sanatison
  • Scalp-Cort
  • Scalpicin Capilar
  • Schericur
  • Scheroson F
  • Sigmacort
  • Signef
  • Stie-Cort
  • Stiefcorcil
  • Synacort
  • Systral Hydrocort
  • Tarcortin
  • Texacort
  • Texacort lotion 25
  • Timocort
  • Transderma H
  • Traumaide
  • Uniderm
  • UNII-WI4X0X7BPJ

Systematic Names

  • Cortisol
  • Hydrocortisone
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-

Mixture Names

  • Cor-Tar-Quin
  • Cort-Quin
  • Cortisporin
  • Drotic
  • Neo-Cort-Dome
  • Nystaform-HC
  • Otalgine
  • Otic-Neo-Cort-Dome
  • Otobiotic
  • Otocort
  • Pediotic Suspension
  • Racet
  • Vioform-Hydrocortisone
  • Vosol HC
  • Vytone
  • Xerese

Registry Numbers

CAS Registry Number

  • 50-23-7

FDA UNII

  • WI4X0X7BPJ

Other Registry Numbers

  • 1050676-88-4
  • 8056-08-4
  • 80562-38-5
  • 8063-42-1

System Generated Number

  • 0000050237

Structure Descriptors

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

JYGXADMDTFJGBT-VWUMJDOOSA-N

Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 400mg/kg/10D- (400mg/kg) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS Psychopharmacology Vol. 145, Pg. 260, 1999.
mouse LD50 subcutaneous > 500mg/kg (500mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
rat LD50 subcutaneous 449mg/kg (449mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 220 deg C   EXP
log P (octanol-water) 1.61 (none)   EXP
Water Solubility 320 mg/L 25 EXP
Vapor Pressure 1.35E-13 mm Hg 25 EST
Henry's Law Constant 5.77E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.14E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.