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Substance Name: Prednisolone [INN:BAN:JAN]
RN: 50-24-8
UNII: 9PHQ9Y1OLM
InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N

Note

  • A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Molecular Formula

  • C21-H28-O5

Molecular Weight

  • 360.4472
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Antiviral (COVID-19)
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Prednisolone
  • Prednisolone [INN:BAN:JAN]

MeSH Heading

  • Prednisolone

Synonyms

  • (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • 1,2-Dehydrohydrocortisone
  • 1,4-Pregnadien-11-beta,17-alpha,21-triol-3,20-dione
  • 1,4-Pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
  • 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
  • 1,4-Pregnadiene-3,20-dione-11-beta,17-alpha,21-triol
  • 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
  • 1-Dehydrohydrocortisone
  • 11-beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene
  • 4-08-00-03467 (Beilstein Handbook Reference)
  • BRN 1354103
  • Bubbli-Pred
  • CCRIS 980
  • CO-Hydeltra
  • Codelcortone
  • Cordrol
  • Cortalone
  • Cotogesic
  • Cotolone
  • Decaprednil
  • Decortin H
  • Delcortol
  • delta F
  • delta(1)-Cortisol
  • delta(1)-Dehydrocortisol
  • delta(1)-Hydrocortisone
  • delta(sup 1)-Cortisol
  • delta(sup 1)-Dehydrocortisol
  • delta(sup 1)-Dehydrohydrocortisone
  • delta(sup 1)-Hydrocortisone
  • delta-Cortef
  • delta-Ef-Cortelan
  • delta-stab
  • Deltacortenol
  • Deltacortril
  • Deltahydrocortisone
  • Deltisilone
  • Derpo PD
  • Dexa-Cortidelt hostacortin H
  • Di-adreson F
  • Dicortol
  • Donisolone
  • Dydeltrone
  • Eazolin D
  • EC 200-021-7
  • EINECS 200-021-7
  • Erbacort
  • Erbasona
  • Estilsona
  • Fernisolone
  • Fernisolone P
  • Fernisolone-P
  • Hostacortin H
  • HSDB 3385
  • Hydeltra
  • Hydeltrone
  • Hydrodeltalone
  • Hydrodeltisone
  • Hydroretrocortin
  • Hydroretrocortine
  • K 1557
  • Lentosone
  • Metacortandralone
  • Meti-Derm
  • Meticortelone
  • NSC 9120
  • Orapred
  • Orapred ODT
  • Paracortol
  • Paracotol
  • Pediapred
  • PRDL
  • Precortancyl
  • Precortilon
  • Precortisyl
  • Predne-Dome
  • Prednelan
  • Prednicen
  • Predniliderm
  • Predniretard
  • Prednis
  • Prednisolona
  • Prednisolona [INN-Spanish]
  • Prednisolone
  • Prednisolonum
  • Prednisolonum [INN-Latin]
  • Predonin
  • Predonine
  • Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-
  • Prelone
  • Prenolone
  • Rolisone
  • Scherisolon
  • Solone
  • Steran
  • Sterane
  • Sterolone
  • Ulacort
  • Ultracorten H
  • Ultracortene-H
  • UNII-9PHQ9Y1OLM

Systematic Names

  • Prednisolone
  • Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy- (8CI)

Mixture Names

  • K-Predne-Dome
  • T-Pred

Registry Numbers

CAS Registry Number

  • 50-24-8

FDA UNII

  • 9PHQ9Y1OLM

Other Registry Numbers

  • 58201-11-9
  • 8056-11-9

System Generated Number

  • 0000050248

Structure Descriptors

InChI

InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Smiles

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 9mg/kg/2W-I (9mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984.
mouse LD50 intraperitoneal 65mg/kg (65mg/kg)   Indian Drugs. Vol. 22, Pg. 529, 1985.
mouse LD50 intravenous 180mg/kg (180mg/kg)   Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982.
mouse LD50 oral 1680mg/kg (1680mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970.
mouse LD50 subcutaneous > 3500mg/kg (3500mg/kg)   Drugs in Japan Vol. 6, Pg. 710, 1982.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg)   Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat LD50 intravenous 120mg/kg (120mg/kg)   Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982.
rat LD50 subcutaneous 147mg/kg (147mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
women TDLo oral 14mg/kg/13D-I (14mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 235 deg C   EXP
log P (octanol-water) 1.62 (none)   EXP
Water Solubility 223 mg/L 25 EXP
Vapor Pressure 1.18E-13 mm Hg 25 EST
Henry's Law Constant 2.71E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.25E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.