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Substance Name: Prednisolone [INN:BAN:JAN]
RN: 50-24-8
UNII: 9PHQ9Y1OLM
InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N
Note
- A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Molecular Formula
- C21-H28-O5
Molecular Weight
- 360.4472
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Mutation Data
- Reproductive Effect
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Links to Resources
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Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Prednisolone
- Prednisolone [INN:BAN:JAN]
MeSH Heading
- Prednisolone
Synonyms
- (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
- 1,2-Dehydrohydrocortisone
- 1,4-Pregnadien-11-beta,17-alpha,21-triol-3,20-dione
- 1,4-Pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
- 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
- 1,4-Pregnadiene-3,20-dione-11-beta,17-alpha,21-triol
- 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
- 1-Dehydrohydrocortisone
- 11-beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione
- 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione
- 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene
- 4-08-00-03467 (Beilstein Handbook Reference)
- BRN 1354103
- Bubbli-Pred
- CCRIS 980
- CO-Hydeltra
- Codelcortone
- Cordrol
- Cortalone
- Cotogesic
- Cotolone
- Decaprednil
- Decortin H
- Delcortol
- delta F
- delta(1)-Cortisol
- delta(1)-Dehydrocortisol
- delta(1)-Hydrocortisone
- delta(sup 1)-Cortisol
- delta(sup 1)-Dehydrocortisol
- delta(sup 1)-Dehydrohydrocortisone
- delta(sup 1)-Hydrocortisone
- delta-Cortef
- delta-Ef-Cortelan
- delta-stab
- Deltacortenol
- Deltacortril
- Deltahydrocortisone
- Deltisilone
- Derpo PD
- Dexa-Cortidelt hostacortin H
- Di-adreson F
- Dicortol
- Donisolone
- Dydeltrone
- Eazolin D
- EC 200-021-7
- EINECS 200-021-7
- Erbacort
- Erbasona
- Estilsona
- Fernisolone
- Fernisolone P
- Fernisolone-P
- Hostacortin H
- HSDB 3385
- Hydeltra
- Hydeltrone
- Hydrodeltalone
- Hydrodeltisone
- Hydroretrocortin
- Hydroretrocortine
- K 1557
- Lentosone
- Metacortandralone
- Meti-Derm
- Meticortelone
- NSC 9120
- Orapred
- Orapred ODT
- Paracortol
- Paracotol
- Pediapred
- PRDL
- Precortancyl
- Precortilon
- Precortisyl
- Predne-Dome
- Prednelan
- Prednicen
- Predniliderm
- Predniretard
- Prednis
- Prednisolona
- Prednisolona [INN-Spanish]
- Prednisolone
- Prednisolonum
- Prednisolonum [INN-Latin]
- Predonin
- Predonine
- Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
- Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-
- Prelone
- Prenolone
- Rolisone
- Scherisolon
- Solone
- Steran
- Sterane
- Sterolone
- Ulacort
- Ultracorten H
- Ultracortene-H
- UNII-9PHQ9Y1OLM
Systematic Names
- Prednisolone
- Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
- Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-
Mixture Names
- K-Predne-Dome
- T-Pred
Registry Numbers
CAS Registry Number
- 50-24-8
FDA UNII
- 9PHQ9Y1OLM
Other Registry Numbers
- 58201-11-9
- 8056-11-9
System Generated Number
- 0000050248
Structure Descriptors
InChI
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1InChIKey
OIGNJSKKLXVSLS-VWUMJDOOSA-NSmiles
C[C@]12C[C@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 9mg/kg/2W-I (9mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
mouse | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | Indian Drugs. Vol. 22, Pg. 529, 1985. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. | |
mouse | LD50 | oral | 1680mg/kg (1680mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970. | |
mouse | LD50 | subcutaneous | > 3500mg/kg (3500mg/kg) | Drugs in Japan Vol. 6, Pg. 710, 1982. | |
rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Advances in Teratology. Vol. 3, Pg. 181, 1968. | |
rat | LD50 | intravenous | 120mg/kg (120mg/kg) | Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. | |
rat | LD50 | subcutaneous | 147mg/kg (147mg/kg) | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. | |
women | TDLo | oral | 14mg/kg/13D-I (14mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 235 | deg C | EXP | |
log P (octanol-water) | 1.62 | (none) | EXP | |
Water Solubility | 223 | mg/L | 25 | EXP |
Vapor Pressure | 1.18E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 2.71E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 7.25E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.