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Substance Name: Estradiol [USP:INN:BAN]
RN: 50-28-2
UNII: 4TI98Z838E
InChIKey: VOXZDWNPVJITMN-ZBRFXRBCSA-N

Note

  • The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

Molecular Formula

  • C18-H24-O2

Molecular Weight

  • 272.3856
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Estrogen
  • Estrogens
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Reasonably Anticipated to be a Carcinogen

Names and Synonyms

Name of Substance

  • Estradiol
  • Estradiol [USP:INN:BAN]

MeSH Heading

  • Estradiol

Synonyms

  • 1,3,5-Estratriene-3,17-beta-diol
  • 17-beta-Estra-1,3,5(10)-triene-3,17-diol
  • 17-beta-Oestra-1,3,5(10)-triene-3,17-diol
  • 17-beta-OH-estradiol
  • 17-beta-OH-oestradiol
  • 17beta-Estradiol
  • 17beta-Oestra-1,3,5(10)-triene-3,17-diol
  • 3,17-beta-Dihydroxy-1,3,5(10)-oestratriene
  • 3,17-beta-Dihydroxyestra-1,3,5(10)-triene
  • 3,17-beta-Dihydroxyoestra-1,3,5-triene
  • 3,17-beta-Estradiol
  • 3,17-beta-Oestradiol
  • 3,17-Epidihydroxyestratriene
  • 3,17-Epidihydroxyoestratriene
  • 3,17beta-Dihydroxyestra-1,3,5-triene
  • 3,17beta-Dihydroxyoestra-1,3,5-triene
  • Aerodiol
  • Alora
  • alpha-Estradiol
  • Altrad
  • Aquadiol
  • Bardiol
  • Beta-estradiol
  • CCRIS 280
  • Climaderm
  • Climara
  • Climara Forte
  • Compudose
  • Compudose 200
  • Compudose 365
  • Corpagen
  • D-3,17-beta-Estradiol
  • D-3,17-beta-Oestradiol
  • D-3,17beta-Estradiol
  • D-3,17beta-Oestradiol
  • d-Estradiol
  • D-Oestradiol
  • Dermestril
  • Dihydrofollicular hormone
  • Dihydrofolliculin
  • Dihydromenformon
  • Dihydrotheelin
  • Dihydroxyestrin
  • Dihydroxyoestrin
  • Dimenformon
  • Diogyn
  • Diogynets
  • Divigel
  • E(sub 2)
  • EC 200-023-8
  • EINECS 200-023-8
  • Elestrim
  • Elestrin
  • Encore
  • Esclim
  • Estra-1,3,5(10)-triene-3,17-beta-diol
  • Estra-1,3,5(10)-triene-3,17-diol, (17beta)-
  • Estra-1,3,5(10)-triene-3,17beta-diol
  • Estrace
  • Estraderm
  • Estraderm MX
  • Estraderm TTS
  • Estraderm TTS 50
  • Estradiol
  • Estradiol-17-beta
  • Estradiol-3,17beta
  • Estradiolo
  • Estradiolo [DCIT]
  • Estradiolum
  • Estradiolum [INN]
  • Estraldine
  • Estrapak 50
  • Estrasorb
  • Estreva
  • Estrifam
  • Estring
  • Estring Vaginal Ring
  • Estroclim
  • Estroclim 50
  • Estrodiolum
  • Estrodiolum [INN-Latin]
  • Estrofem 2
  • Estrofem forte
  • Estrogel
  • Estrogens, esterified
  • Estrovite
  • Evamist
  • Evorel
  • Extrasorb
  • Femestral
  • Femogen
  • Fempatch
  • Femtran
  • Follicyclin
  • Ginedisc
  • Ginosedol
  • Gynergon
  • Gynestrel
  • Gynodiol
  • Gynoestryl
  • GynPolar
  • HSDB 3589
  • Innofem
  • Lamdiol
  • Macrodiol
  • Macrol
  • Menest
  • Menorest
  • Menostar
  • Microdiol
  • Minivelle
  • Nordicol
  • NSC-9895
  • Oesclim
  • Oestergon
  • Oestra-1,3,5(10)-triene-3,17-beta-diol
  • Oestra-1,3,5(10)-triene-3,17beta-diol
  • Oestradiol
  • Oestradiol Berco
  • Oestradiol R
  • Oestradiol-17-beta
  • Oestradiol-17beta
  • Oestradiolum
  • Oestroglandol
  • Oestrogynal
  • Ovahormon
  • Ovasterol
  • Ovastevol
  • Ovociclina
  • Ovocyclin
  • Ovocycline
  • Perlatanol
  • Primofol
  • Profoliol
  • Progynon
  • Progynon DH
  • Progynon-DH
  • Sandrena Gel
  • Sisare Gel
  • SK-Estrogens
  • Syndiol
  • Systen
  • Theelin, dihydro-
  • Tradelia
  • Trial SAT
  • Trocosone
  • TX-004HR
  • UNII-4TI98Z838E
  • Vagifem
  • Vivelle
  • Vivelle-dot
  • Yuvvexy
  • Zerella
  • Zesteem
  • Zumenon

Systematic Names

  • 17beta-Estradiol
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-
  • Estra-1,3,5(10)-triene-3,17-diol, (17beta)-
  • Estradiol

Superlist Names

  • Estra-1,3,5(10)-triene-3,17-diol, (17beta)-
  • Estradiol-17beta
  • Oestradiol
  • Oestradiol-17beta
  • Oestradiol-17beta and esters
  • Oestradiol-17beta and esters [Steroidal oestrogens]

Mixture Names

  • Activella
  • Climara Pro
  • Combipatch

Registry Numbers

CAS Registry Number

  • 50-28-2

FDA UNII

  • 4TI98Z838E

Other Registry Numbers

  • 1050677-52-5
  • 1206475-11-7
  • 873662-39-6

System Generated Number

  • 0000050282

Structure Descriptors

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChIKey

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Smiles

C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD subcutaneous > 300mg/kg (300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 178.5 deg C   EXP
log P (octanol-water) 4.01 (none)   EXP
Water Solubility 3.6 mg/L 27 EXP
Vapor Pressure 1.26E-08 mm Hg 25 EST
Henry's Law Constant 3.64E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.23E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.