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Substance Name: Oxytocin [USP:INN:BAN:JAN]
RN: 50-56-6
UNII: 1JQS135EYN
InChIKey: XNOPRXBHLZRZKH-DSZYJQQASA-N
Note
- A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on smooth muscle cells, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
Molecular Formula
- C43-H66-N12-O12-S2
Molecular Weight
- 1007.1984
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Hormone
- Human Data
- Oxytocic
- Oxytocics
- Reproductive Control Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Oxytocin
- Oxytocin [USP:INN:BAN:JAN]
MeSH Heading
- Oxytocin
Synonyms
- (1-Hemicystine)oxytocin
- 3-Isoleucine-8-leucine vasopressin
- alpha-Hypophamine
- Atonin O
- BRN 3586108
- Di-sipidin
- EINECS 200-048-4
- Endopituitrina
- HSDB 2182
- L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic (1-6)-disulfide
- Nobitocin S
- Ocytocin
- Ocytocinum
- Orasthin
- Ossitocina
- Ossitocina [DCIT]
- Oxetakain
- Oxetakain [Czech]
- Oxitocina
- Oxitocina [INN-Spanish]
- Oxoject
- Oxystin
- Oxytocin
- Oxytocin 10 USP units in dextrose 5%
- Oxytocin 20 USP units in dextrose 5%
- Oxytocin 5 USP units in dextrose 5%
- Oxytocine
- Oxytocine [INN-French]
- Oxytocinum
- Oxytocinum [INN-Latin]
- Partocon
- Pitocin
- Piton S
- Posterior pituitary extract
- Presoxin
- Synpitan
- Synthetic oxytocin
- Syntocin
- Syntocinon
- Syntocinone
- UNII-1JQS135EYN
- Utedrin
- Uteracon
- Vasopressin, 3-L-isoleucine-8-L-leucine-
Systematic Name
- Oxytocin
Registry Numbers
CAS Registry Number
- 50-56-6
FDA UNII
- 1JQS135EYN
System Generated Number
- 0000050566
Structure Descriptors
InChI
1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1InChIKey
XNOPRXBHLZRZKH-DSZYJQQASA-NSmiles
CC[C@H](C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 5800ug/kg (5.8mg/kg) | Drugs in Japan Vol. 6, Pg. 151, 1982. | |
| mouse | LD50 | oral | > 514mg/kg (514mg/kg) | Drugs in Japan Vol. -, Pg. 230, 1990. | |
| mouse | LD50 | subcutaneous | > 514mg/kg (514mg/kg) | Drugs in Japan Vol. -, Pg. 230, 1990. | |
| rat | LD50 | intravenous | 2275ug/kg (2.275mg/kg) | Drugs in Japan Vol. -, Pg. 230, 1990. | |
| rat | LD50 | oral | > 20520ug/kg (20.52mg/kg) | Drugs in Japan Vol. -, Pg. 230, 1990. | |
| rat | LD50 | subcutaneous | > 20520ug/kg (20.52mg/kg) | Drugs in Japan Vol. -, Pg. 230, 1990. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | -6.270 | (none) | EST | |
| Atmospheric OH Rate Constant | 5.33E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.