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Substance Name: Niclosamide [USAN:INN:BAN]
RN: 50-65-7
UNII: 8KK8CQ2K8G
InChIKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Note

  • An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48).

Molecular Formula

  • C13-H8-Cl2-N2-O4

Molecular Weight

  • 327.1222
 

Classification Codes

  • Agricultural Chemical
  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Anticestodal Agents
  • Antinematodal Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Antiviral (COVID-19)
  • Drug / Therapeutic Agent
  • Molluscacides
  • Mutation Data
  • Nematocide
  • Pesticides
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Niclosamide
  • Niclosamide [BSI:ISO]
  • Niclosamide [USAN:INN:BAN]

MeSH Heading

  • Niclosamide

Synonyms

  • 2',5-Dichlor-4'-nitro-salizylsaeureanilid
  • 2',5-Dichlor-4'-nitro-salizylsaeureanilid [German]
  • 2',5-Dichloro-4'-nitrosalicylanilide
  • 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
  • 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
  • 5-Chloro-2'-chloro-4'-nitrosalicylanilide
  • 5-Chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide
  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
  • 5-Chlorosalicyloyl-(o-chloro-p-nitranilide)
  • AI3-25823
  • Atenase
  • B 2353
  • BAY 2353
  • Bayer 2353
  • Bayer 73
  • Bayluscid
  • Bayluscide
  • Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
  • BRN 2820605
  • CCRIS 3437
  • Cestocid
  • Chemagro 2353
  • Clonitralide
  • Devermin
  • Devermine
  • Dichlosale
  • EINECS 200-056-8
  • ENT 25823
  • Fedal-Telmin
  • Fenasal
  • Helmiantin
  • HL 2447
  • HSDB 1572
  • Iomesan
  • Iomezan
  • Lintex
  • Mansonil
  • Mato
  • N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid
  • N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid [German]
  • N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide
  • Nasemo
  • Niclocide
  • Niclosamida
  • Niclosamida [INN-Spanish]
  • Niclosamide
  • Niclosamidum
  • Niclosamidum [INN-Latin]
  • Nitrophenyl chlorsalicylamide
  • NSC 178296
  • Phenasal
  • Radeverm
  • Radewerm
  • Sagimid
  • Salicylanilide, 2',5-dichloro-4'-nitro-
  • SR 73
  • Sulqui
  • Tredemine
  • UNII-8KK8CQ2K8G
  • Vermitid
  • Vermitin
  • WR 46234
  • Yomesan
  • Zestocarp

Systematic Names

  • Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
  • Niclosamide
  • Salicylanilide, 2',5-dichloro-4'-nitro-

Registry Numbers

CAS Registry Number

  • 50-65-7

FDA UNII

  • 8KK8CQ2K8G

Related Registry Number

  • 1420-04-8 (2-aminoethanol (1:1))

System Generated Number

  • 0000050657

Structure Descriptors

InChI

InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChIKey

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Smiles

Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD oral > 1gm/kg (1000mg/kg)   French Medicament Patent Document. Vol. #2628M,
mouse LD50 intravenous 7500ug/kg (7.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 884, 1960.
mouse LD50 oral 1gm/kg (1000mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rabbit LD oral > 5gm/kg (5000mg/kg)   French Medicament Patent Document. Vol. #2628M,
rat LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Zeitschrift fuer Tropenmedizin und Parasitologie. Vol. 13, Pg. 1, 1962.
rat LD50 oral 2500mg/kg (2500mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A297, Pg. 1983,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 230 deg C   EXP
log P (octanol-water) 4.560 (none)   EST
Water Solubility 1.6 mg/L 20 EXP
Vapor Pressure 1.49E-11 mm Hg 20 EXP
Henry's Law Constant 4.00E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.46E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.