|
|
Substance Name: Niclosamide [USAN:INN:BAN]
RN: 50-65-7
UNII: 8KK8CQ2K8G
InChIKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Note
- An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48).
Molecular Formula
- C13-H8-Cl2-N2-O4
Molecular Weight
- 327.1222
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Agricultural Chemical
- Anthelmintic
- Anthelmintics
- Anti-Infective Agents
- Anticestodal Agents
- Antinematodal Agents
- Antiparasitic Agents
- Antiplatyhelmintic Agents
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Molluscacides
- Mutation Data
- Nematocide
- Pesticides
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Niclosamide
- Niclosamide [BSI:ISO]
- Niclosamide [USAN:INN:BAN]
MeSH Heading
- Niclosamide
Synonyms
- 2',5-Dichlor-4'-nitro-salizylsaeureanilid
- 2',5-Dichlor-4'-nitro-salizylsaeureanilid [German]
- 2',5-Dichloro-4'-nitrosalicylanilide
- 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
- 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
- 5-Chloro-2'-chloro-4'-nitrosalicylanilide
- 5-Chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide
- 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
- 5-Chlorosalicyloyl-(o-chloro-p-nitranilide)
- AI3-25823
- Atenase
- B 2353
- BAY 2353
- Bayer 2353
- Bayer 73
- Bayluscid
- Bayluscide
- Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
- BRN 2820605
- CCRIS 3437
- Cestocid
- Chemagro 2353
- Clonitralide
- Devermin
- Devermine
- Dichlosale
- EINECS 200-056-8
- ENT 25823
- Fedal-Telmin
- Fenasal
- Helmiantin
- HL 2447
- HSDB 1572
- Iomesan
- Iomezan
- Lintex
- Mansonil
- Mato
- N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid
- N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid [German]
- N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide
- Nasemo
- Niclocide
- Niclosamida
- Niclosamida [INN-Spanish]
- Niclosamide
- Niclosamidum
- Niclosamidum [INN-Latin]
- Nitrophenyl chlorsalicylamide
- NSC 178296
- Phenasal
- Radeverm
- Radewerm
- Sagimid
- Salicylanilide, 2',5-dichloro-4'-nitro-
- SR 73
- Sulqui
- Tredemine
- UNII-8KK8CQ2K8G
- Vermitid
- Vermitin
- WR 46234
- Yomesan
- Zestocarp
Systematic Names
- Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
- Niclosamide
- Salicylanilide, 2',5-dichloro-4'-nitro-
Registry Numbers
CAS Registry Number
- 50-65-7
FDA UNII
- 8KK8CQ2K8G
Related Registry Number
- 1420-04-8 (2-aminoethanol (1:1))
System Generated Number
- 0000050657
Structure Descriptors
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)InChIKey
RJMUSRYZPJIFPJ-UHFFFAOYSA-NSmiles
Oc1ccc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD | oral | > 1gm/kg (1000mg/kg) | French Medicament Patent Document. Vol. #2628M, | |
mouse | LD50 | intravenous | 7500ug/kg (7.5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 884, 1960. |
mouse | LD50 | oral | 1gm/kg (1000mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
rabbit | LD | oral | > 5gm/kg (5000mg/kg) | French Medicament Patent Document. Vol. #2628M, | |
rat | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Zeitschrift fuer Tropenmedizin und Parasitologie. Vol. 13, Pg. 1, 1962. |
rat | LD50 | oral | 2500mg/kg (2500mg/kg) | "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A297, Pg. 1983, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 230 | deg C | EXP | |
log P (octanol-water) | 4.560 | (none) | EST | |
Water Solubility | 1.6 | mg/L | 20 | EXP |
Vapor Pressure | 1.49E-11 | mm Hg | 20 | EXP |
Henry's Law Constant | 4.00E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 9.46E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.