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Substance Name: Serotonin
RN: 50-67-9
UNII: 333DO1RDJY
InChIKey: QZAYGJVTTNCVMB-UHFFFAOYSA-N
Note
- A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Molecular Formula
- C10-H12-N2-O
Molecular Weight
- 176.2178
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Neurotransmitter Agents
- Reproductive Effect
- Serotonin Agents
- Serotonin Receptor Agonists
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Names and Synonyms
Name of Substance
- Serotonin
MeSH Heading
- Serotonin
Synonyms
- 3-(2-Aminoethyl)-1H-indol-5-ol
- 3-(2-Aminoethyl)indol-5-ol
- 3-(beta-Aminoethyl)-5-hydroxyindole
- 5-22-12-00016 (Beilstein Handbook Reference)
- 5-HT
- 5-Hta
- 5-Hydroxy-3-(beta-aminoethyl)indole
- 5-Hydroxytryptamine
- Antemoqua
- Antemovis
- BRN 0143524
- Ds substance
- EINECS 200-058-9
- Enteramine
- Hippophain
- Hippophaine
- Serotonin
- Serotonine
- Substance DS
- Substanz DS
- Thrombocytin
- Thrombotonin
- Tryptamine, 5-hydroxy-
- UNII-333DO1RDJY
Systematic Names
- 1H-Indol-5-ol, 3-(2-aminoethyl)-
- 3-(2-Aminoethyl)indol-5-ol
- Indol-5-ol, 3-(2-aminoethyl)-
Registry Numbers
CAS Registry Number
- 50-67-9
FDA UNII
- 333DO1RDJY
System Generated Number
- 0000050679
Structure Descriptors
InChI
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2InChIKey
QZAYGJVTTNCVMB-UHFFFAOYSA-NSmiles
NCCc1c[nH]c2ccc(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 5mg/kg (5mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
guinea pig | LD50 | intravenous | 12800ug/kg (12.8mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 168, Pg. 373, 1967. | |
mouse | LD50 | intramuscular | 750mg/kg (750mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 319, 1957. | |
mouse | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Indian Journal of Physiology and Pharmacology. Vol. 17, Pg. 31, 1973. | |
mouse | LD50 | intravenous | 81mg/kg (81mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
mouse | LD50 | oral | 60mg/kg (60mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (3), Pg. 61, 1985. | |
mouse | LD50 | subcutaneous | 601mg/kg (601mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
mouse | LD50 | unreported | 250mg/kg (250mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 122, 1982. | |
rat | LD50 | intravenous | 30mg/kg (30mg/kg) | Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963. | |
rat | LD50 | subcutaneous | 285mg/kg (285mg/kg) | Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 167.5 | deg C | EXP | |
pKa Dissociation Constant | 9.97 | (none) | 25 | EXP |
log P (octanol-water) | 0.21 | (none) | EXP | |
Water Solubility | 2.00E+04 | mg/L | 27 | EXP |
Vapor Pressure | 1.91E-06 | mm Hg | 25 | EST |
Henry's Law Constant | 1.39E-14 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.33E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.