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Substance Name: Sorbitol [USP:NF]
RN: 50-70-4
UNII: 506T60A25R
InChIKey: FBPFZTCFMRRESA-JGWLITMVSA-N

Note

  • A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Molecular Formula

  • C6-H14-O6

Molecular Weight

  • 182.171
 

Classification Codes

  • Cathartics
  • Flavoring Agents
  • Food Additives
  • Gastrointestinal Agents
  • Human Data
  • Indicators and Reagents
  • Mutation Data
  • Pharmaceutic Aid (Flavor)
  • Pharmaceutic Aid (Tablet Excipient)
  • Sweetening Agents

Names and Synonyms

Name of Substance

  • D-Glucitol
  • D-Sorbitol
  • Sorbitol
  • Sorbitol [USP:NF]

MeSH Heading

  • Sorbitol

Synonyms

  • (-)-Sorbitol
  • AI3-19424
  • CCRIS 1898
  • Cholaxine
  • D-(-)-Sorbitol
  • D-1,2,3,4,5,6-Hexanehexol
  • D-Glucitol
  • D-Sorbite
  • D-Sorbitol
  • D-Sorbol
  • Diakarmon
  • EINECS 200-061-5
  • Esasorb
  • FEMA No. 3029
  • Foodol D 70
  • Glucarine
  • Glucitol
  • Gulitol
  • Hexahydric alcohol
  • HSDB 801
  • Karion
  • Karion (carbohydrate)
  • Karion instant
  • L-Gulitol
  • Medevac
  • Multitol
  • Neosorb
  • Neosorb 20/60DC
  • Neosorb 70/02
  • Neosorb 70/70
  • Neosorb P 20/60
  • Neosorb P 60
  • Nivitin
  • NSC 25944
  • Sionit
  • Sionit K
  • Sionite
  • Sionon
  • Siosan
  • Sorbex M
  • Sorbex R
  • Sorbex RP
  • Sorbex S
  • Sorbex X
  • Sorbicolan
  • Sorbilande
  • Sorbite
  • Sorbitol
  • Sorbitol 3% in plastic container
  • Sorbitol 3.3% in plastic container
  • Sorbitol F
  • Sorbitol FP
  • Sorbitol syrup C
  • Sorbo
  • Sorbol
  • Sorbostyl
  • Sorvilande
  • UNII-506T60A25R

Systematic Names

  • D-Glucitol
  • D-Sorbitol
  • Glucitol

Superlist Names

  • 1,2,3,4,5,6-Hexanehexol
  • Glucitol, D-
  • Sorbitol
  • Sorbitol solutions

Mixture Name

  • Probilagol

Registry Numbers

CAS Registry Number

  • 50-70-4

FDA UNII

  • 506T60A25R

Other Registry Numbers

  • 15060-73-8
  • 36134-87-9
  • 3959-53-3
  • 63800-20-4
  • 75398-79-7
  • 8013-15-8
  • 8014-89-9
  • 8036-93-9
  • 8042-39-5
  • 8045-74-7
  • 8046-05-7
  • 952319-42-5
  • 98201-93-5

System Generated Number

  • 0000050704

Structure Descriptors

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey

FBPFZTCFMRRESA-JGWLITMVSA-N

Smiles

O[C@@H]([C@@H]([C@H](CO)O)O)[C@@H](CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 15gm/kg (15000mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 98, 1936.
mouse LD50 intravenous 9480mg/kg (9480mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
mouse LD50 oral 17800mg/kg (17800mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
mouse LD50 subcutaneous 24gm/kg (24000mg/kg)   Drugs in Japan Vol. -, Pg. 607, 1990.
rat LD50 intravenous 7100mg/kg (7100mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 498, 1974.
rat LD50 oral 15900mg/kg (15900mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 498, 1974.
rat LD50 subcutaneous 29600mg/kg (29600mg/kg)   Drugs in Japan Vol. -, Pg. 607, 1990.
women TDLo oral 1700mg/kg/D (1700mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" American Journal of Digestive Diseases. Vol. 23, Pg. 568, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 11 deg C   EXP
pKa Dissociation Constant 13.57 (none)   EXP
log P (octanol-water) -2.20E+00 (none)   EXP
Water Solubility 2.75E+06 mg/L 30 EXP
Vapor Pressure 4.92E-09 mm Hg 25 EST
Henry's Law Constant 7.26E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.00E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.