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Substance Name: Eucaine
RN: 500-34-5
UNII: 7X49L994AY
InChIKey: ZYHGIAPHLSTGMX-WCQYABFASA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H21-N-O2

Molecular Weight

  • 247.3359
 
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Names and Synonyms

Results Name

  • Eucaine

Name of Substance

  • beta-Eucaine

Synonyms

  • 2,2,6-Trimethyl-4-piperidinol benzoate (ester)
  • beta-Eucaine
  • Betacain
  • Eucain B
  • Eucaine B
  • Eukain B
  • NSC 49860
  • UNII-7X49L994AY

Systematic Names

  • 4-Piperidinol, 2,2,6-trimethyl-, benzoate (ester)
  • 4-Piperidinol, 2,2,6-trimethyl-, benzoate (ester), stereoisomer (VAN) (8CI)

Registry Numbers

CAS Registry Number

  • 500-34-5

FDA UNII

  • 7X49L994AY

Other Registry Numbers

  • 25334-04-7
  • 46917-18-4
  • 772990-62-2

System Generated Number

  • 0000500345

Structure Descriptors

InChI

1S/C15H21NO2/c1-11-9-13(10-15(2,3)16-11)18-14(17)12-7-5-4-6-8-12/h4-8,11,13,16H,9-10H2,1-3H3/t11-,13+/m0/s1

InChIKey

ZYHGIAPHLSTGMX-WCQYABFASA-N

Smiles

C[C@H]1C[C@H](CC(C)(C)N1)OC(=O)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 10mg/kg (10mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
guinea pig LDLo intraperitoneal 18mg/kg (18mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
guinea pig LDLo intravenous 30mg/kg (30mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
guinea pig LDLo subcutaneous 310mg/kg (310mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
mouse LDLo intravenous 71mg/kg (71mg/kg) BEHAVIORAL: GENERAL ANESTHETIC "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936.
rabbit LDLo subcutaneous 400mg/kg (400mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.
rat LDLo intravenous 15mg/kg (15mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 70.5 deg C   EXP
log P (octanol-water) 2.950 (none)   EST
Water Solubility 2960 mg/L 20 EXP
Vapor Pressure 3.48E-05 mm Hg 25 EST
Henry's Law Constant 1.89E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.50E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.