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Substance Name: Thiambutosine [INN:BAN]
RN: 500-89-0
UNII: X92J960C7P
InChIKey: JYCBKPOKWDDOOV-UHFFFAOYSA-N

Note

  • Thiourea antileprotic agent used in patients who cannot tolerate sulfones.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H25-N3-O-S

Molecular Weight

  • 343.492
 
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Names and Synonyms

Name of Substance

  • Thiambutosine
  • Thiambutosine [INN:BAN]

Synonyms

  • 4-13-00-01179 (Beilstein Handbook Reference)
  • 4-Butoxy-4'-(dimethylamino)thiocarbanilide
  • BRN 2819159
  • Ciba 1906
  • EINECS 207-914-0
  • NSC 682
  • SU 1906
  • Summit 1906
  • Thiambutosine
  • Thiambutosinum
  • Thiambutosinum [INN-Latin]
  • Tiambutosina
  • Tiambutosina [INN-Spanish]
  • UNII-X92J960C7P

Systematic Names

  • 1-(p-Butoxyphenyl)-3-(p-dimethylaminophenyl)-2-thiourea
  • Carbanilide, 4-butoxy-4'-(dimethylamino)thio-
  • Thiambutosine
  • Thiourea, N-(4-butoxyphenyl)-N'-(4-(dimethylamino)phenyl)- (9CI)

Registry Numbers

CAS Registry Number

  • 500-89-0

FDA UNII

  • X92J960C7P

System Generated Number

  • 0000500890

Structure Descriptors

InChI

1S/C19H25N3OS/c1-4-5-14-23-18-12-8-16(9-13-18)21-19(24)20-15-6-10-17(11-7-15)22(2)3/h6-13H,4-5,14H2,1-3H3,(H2,20,21,24)

InChIKey

JYCBKPOKWDDOOV-UHFFFAOYSA-N

Smiles

c1(NC(Nc2ccc(N(C)C)cc2)=S)ccc(OCCCC)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 2400mg/kg (2400mg/kg)   Drugs in Japan Vol. 6, Pg. 453, 1982.
mouse LD50 subcutaneous 2400mg/kg (2400mg/kg)   Drugs in Japan Vol. 6, Pg. 453, 1982.