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Substance Name: Fluphenazine decanoate [USP:BAN:JAN]
RN: 5002-47-1
UNII: FMU62K1L3C
InChIKey: VIQCGTZFEYDQMR-UHFFFAOYSA-N

Molecular Formula

  • C32-H44-F3-N3-O2-S

Molecular Weight

  • 591.7786
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Fluphenazine decanoate [USP:BAN:JAN]
  • Fluphenazine depot

Synonyms

  • 2-(4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl decanoate
  • BRN 0599852
  • CCRIS 3954
  • Dapotum D
  • EINECS 225-672-4
  • Flufenazine decanoate
  • Fluorophenazine decanoate
  • Fluphenazine decanoate
  • Fluphenazine depot
  • Lyogen
  • Modecate
  • Moditen depot
  • NSC 169510
  • Prolixin decanoate
  • SQ 10,733
  • UNII-FMU62K1L3C

Systematic Names

  • Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
  • Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
  • Fluphenaline decanoate
  • Fluphenazine O-decanoate

Registry Numbers

CAS Registry Number

  • 5002-47-1

FDA UNII

  • FMU62K1L3C

System Generated Number

  • 0005002471

Structure Descriptors

InChI

1S/C32H44F3N3O2S/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3

InChIKey

VIQCGTZFEYDQMR-UHFFFAOYSA-N

Smiles

CCCCCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 1500mg/kg (1500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 799, 1993.
human TDLo intramuscular 179ug/kg (0.179mg/kg) BEHAVIORAL: ANTIPSYCHOTIC American Journal of Psychiatry. Vol. 121, Pg. 784, 1965.
man TDLo intramuscular 1071ug/kg/12D (1.071mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER

BEHAVIORAL: ATAXIA
Annals of Emergency Medicine. Vol. 16, Pg. 705, 1987.
man TDLo intramuscular 46mg/kg/5Y-I (46mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) British Journal of Psychiatry. Vol. 149, Pg. 524, 1986.
mouse LD50 intramuscular 60mg/kg (60mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 16, Pg. 87, 1990.
rat LD50 intramuscular 576mg/kg (576mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 16, Pg. 75, 1990.
rat LD50 oral 19mg/kg (19mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 16, Pg. 75, 1990.
rat LD50 oral 19mg/kg (19mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 16, Pg. 75, 1990.
women TDLo intramuscular 21mg/kg/6D-I (21mg/kg) CARDIAC: PULSE RATE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
British Medical Journal. Vol. 286, Pg. 1016, 1983.