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Substance Name: Rilpivirine [USAN:INN]
RN: 500287-72-9
UNII: FI96A8X663
InChIKey: YIBOMRUWOWDFLG-ONEGZZNKSA-N

Note

  • A diarylpyrimidine derivative and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 that is used in the treatment of HIV INFECTIONS. It is also used in combination with other ANTI-HIV AGENTS, since ANTIVIRAL DRUG RESISTANCE emerges rapidly when it is used alone.

Molecular Formula

  • C22-H18-N6

Molecular Weight

  • 366.4262
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • Treatment of HIV Infection

Names and Synonyms

Name of Substance

  • Rilpivirine
  • Rilpivirine [USAN:INN]

MeSH Heading

  • Rilpivirine

Synonyms

  • 4-((4-((4-((1E)-2-Cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile
  • Edurant
  • HSDB 8153
  • R 278474
  • R278474
  • Rilpivirine
  • TMC 278
  • TMC-278
  • TMC278
  • UNII-FI96A8X663

Systematic Name

  • Benzonitrile, 4-((4-((4-((1E)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)-

Registry Numbers

CAS Registry Number

  • 500287-72-9

FDA UNII

  • FI96A8X663

System Generated Number

  • 0500287729

Structure Descriptors

InChI

1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

InChIKey

YIBOMRUWOWDFLG-ONEGZZNKSA-N

Smiles

C(#N)c1ccc(cc1)Nc1nccc(n1)Nc1c(cc(cc1C)/C=C/C#N)C