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Substance Name: Kevetrin
RN: 500863-50-3
UNII: C3059TG1KN
InChIKey: PRDJGNVQBVXXEO-UHFFFAOYSA-N

Note

  • NCI: thioureidobutyronitrile. A water-soluble, molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. (NCI Thesaurus)

Molecular Formula

  • C5-H9-N3-S

Molecular Weight

  • 143.2131
 
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Names and Synonyms

Name of Substance

  • 4-Isothioureidobutyronitrile
  • Kevetrin

Synonyms

  • 4-Isothioureidobutyronitrile
  • Carbamimidothioic acid, 3-cyanopropyl ester
  • NSC-525990
  • thioureidobutyronitrile
  • UNII-C3059TG1KN

Registry Numbers

CAS Registry Number

  • 500863-50-3

FDA UNII

  • C3059TG1KN

System Generated Number

  • 0500863503

Structure Descriptors

InChI

1S/C5H9N3S/c6-3-1-2-4-9-5(7)8/h1-2,4H2,(H3,7,8)

InChIKey

PRDJGNVQBVXXEO-UHFFFAOYSA-N

Smiles

C(CC#N)CSC(=N)N