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Substance Name: Kojic acid
RN: 501-30-4
UNII: 6K23F1TT52
InChIKey: BEJNERDRQOWKJM-UHFFFAOYSA-N

Classification Codes

  • Antioxidants
  • Drug / Therapeutic Agent
  • Mutation Data
  • Protective Agents

Molecular Formula

  • C6-H6-O4

Molecular Weight

  • 142.1094
 
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Names and Synonyms

Name of Substance

  • 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
  • 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
  • Kojic acid

Synonyms

  • 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one
  • 5-18-02-00516 (Beilstein Handbook Reference)
  • 5-Hydroxy-2-(hydroxymethyl)-4-pyrone
  • AI3-02549
  • BRN 0120895
  • CCRIS 4131
  • EINECS 207-922-4
  • HSDB 7664
  • Kojic acid
  • NSC 1942
  • UNII-6K23F1TT52

Systematic Names

  • 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
  • 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
  • 5-Hydroxy-2-hydroxymethyl-4-pyrone
  • Kojic acid

Registry Numbers

CAS Registry Number

  • 501-30-4

FDA UNII

  • 6K23F1TT52

Other Registry Number

  • 123712-78-7

System Generated Number

  • 0000501304

Structure Descriptors

InChI

1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2

InChIKey

BEJNERDRQOWKJM-UHFFFAOYSA-N

Smiles

c1c(occ(c1=O)O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1gm/kg (1000mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1755, 1978.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 393, 1981.
mouse LDLo intravenous 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nature. Vol. 155, Pg. 302, 1945.
mouse LDLo oral 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nature. Vol. 155, Pg. 302, 1945.
mouse LDLo subcutaneous 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nature. Vol. 155, Pg. 302, 1945.
rabbit LDLo intravenous 1gm/kg (1000mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1755, 1978.
rat LDLo intravenous 1gm/kg (1000mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1755, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 153.5 deg C   EXP
log P (octanol-water) -0.64 (none)   EXP
Water Solubility 9.35E+05 mg/L 25 EST
Vapor Pressure 3.21E-06 mm Hg 25 EST
Henry's Law Constant 2.39E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.44E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.