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Substance Name: Lonidamine [INN:BAN]
RN: 50264-69-2
UNII: U78804BIDR
InChIKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N

Molecular Formula

  • C15-H10-Cl2-N2-O2

Molecular Weight

  • 321.162
 

Classification Codes

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Antispermatogenic Agents
  • Contraceptive Agents
  • Contraceptive Agents, Male
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Radiation-Sensitizing Agents
  • Reproductive Control Agents
  • Reproductive Effect
  • Trypanocidal Agents
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Names and Synonyms

Name of Substance

  • Lonidamine
  • Lonidamine [INN:BAN]

Synonyms

  • 1-(2,4-Dichlorbenzyl)-indazole-3-carboxylic acid
  • 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
  • 5-25-04-00250 (Beilstein Handbook Reference)
  • AF 1890
  • BRN 0894483
  • CCRIS 3516
  • DICA
  • Diclondazolic acid
  • Doridamina
  • EINECS 256-510-0
  • Lonidamina
  • Lonidamina [INN-Spanish]
  • Lonidamine
  • Lonidaminum
  • Lonidaminum [INN-Latin]
  • UNII-U78804BIDR

Systematic Names

  • 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
  • 1H-Indazole-3-carboxylic acid, 1-((2,4-dichlorophenyl)methyl)- (9CI)
  • 1H-Indazole-3-carboxylic acid, 1-(2,4-dichlorobenzyl)-
  • Lonidamine

Registry Numbers

CAS Registry Number

  • 50264-69-2

FDA UNII

  • U78804BIDR

Other Registry Number

  • 57571-43-4

System Generated Number

  • 0050264692

Structure Descriptors

InChI

1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)

InChIKey

WDRYRZXSPDWGEB-UHFFFAOYSA-N

Smiles

c12c(c(C(O)=O)nn1Cc1c(cc(Cl)cc1)Cl)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 435mg/kg (435mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,
mouse LD50 oral 900mg/kg (900mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,
rat LD50 intraperitoneal 525mg/kg (525mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,
rat LD50 oral 1700mg/kg (1700mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 207 deg C   EXP
log P (octanol-water) 4.660 (none)   EST
Atmospheric OH Rate Constant 1.60E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.