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Substance Name: Meglutol [USAN:INN]
RN: 503-49-1
UNII: CLA99KCD53
InChIKey: NPOAOTPXWNWTSH-UHFFFAOYSA-N

Note

  • An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

Molecular Formula

  • C6-H10-O5

Molecular Weight

  • 162.14
 

Classification Codes

  • Anticholesteremic Agents
  • Antihyperlipoproteinemic
  • Antimetabolites
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents
  • Lipid Regulating Agents
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Names and Synonyms

Name of Substance

  • Meglutol
  • Meglutol [USAN:INN]

MeSH Heading

  • Meglutol

Synonyms

  • 3-Hydroxy-3-methylglutaric acid
  • 3-Hydroxy-3-methylpentanedioic acid
  • 4-03-00-01166 (Beilstein Handbook Reference)
  • beta-Hydroxy-beta-methylglutaric acid
  • BRN 1769194
  • CB 337
  • CB-337
  • Dicrotalic acid
  • EINECS 207-971-1
  • HMG
  • HMGA
  • Lipoglutaren
  • Medroglutaric acid
  • Meglutol
  • Meglutolum
  • Meglutolum [INN-Latin]
  • NSC 361411
  • UNII-CLA99KCD53

Systematic Names

  • Glutaric acid, 3-hydroxy-3-methyl-
  • Meglutol
  • Pentanedioic acid, 3-hydroxy-3-methyl-

Registry Numbers

CAS Registry Number

  • 503-49-1

FDA UNII

  • CLA99KCD53

System Generated Number

  • 0000503491

Structure Descriptors

InChI

1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)

InChIKey

NPOAOTPXWNWTSH-UHFFFAOYSA-N

Smiles

C(CC(=O)O)(CC(=O)O)(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3230mg/kg (3230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1284, 1975.
mouse LD50 oral 7330mg/kg (7330mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1284, 1975.