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Substance Name: Cefadroxil [INN]
RN: 50370-12-2
UNII: Q525PA8JJB
InChIKey: BOEGTKLJZSQCCD-UEKVPHQBSA-N

Note

  • Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.

Molecular Formula

  • C16-H17-N3-O5-S

Molecular Weight

  • 363.3923
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Results Name

  • Cefadroxil [INN]

Name of Substance

  • Cefadroxil anhydrous
  • Cefadroxil [INN]

MeSH Heading

  • Cefadroxil

Synonyms

  • (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • BL-S 578
  • Cefadroxil
  • Cefadroxilo
  • Cefadroxilo [INN-Spanish]
  • Cefadroxilum
  • Cefadroxilum [INN-Latin]
  • Cephadroxil
  • D-Cefadroxil
  • EINECS 256-555-6
  • Oracefal
  • S 578
  • S-578
  • UNII-Q525PA8JJB

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R,7R)-
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R-(6-alpha,7-beta(R*)))-
  • Cefadroxil

Registry Numbers

CAS Registry Number

  • 50370-12-2

FDA UNII

  • Q525PA8JJB

System Generated Number

  • 0050370122

Structure Descriptors

InChI

1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1

InChIKey

BOEGTKLJZSQCCD-UEKVPHQBSA-N

Smiles

c1(ccc(cc1)O)[C@H](C(=O)N[C@H]1[C@@H]2N(C(=C(CS2)C)C(=O)O)C1=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
mouse LD50 intravenous > 1500mg/kg (1500mg/kg)   Infection. Vol. 8(Suppl,
mouse LD50 oral > 10gm/kg (10000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
mouse LD50 subcutaneous > 8gm/kg (8000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
rabbit LD50 oral > 6gm/kg (6000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
rat LD50 intraperitoneal > 6gm/kg (6000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.
rat LD50 intravenous > 1gm/kg (1000mg/kg)   Infection. Vol. 8(Suppl,
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 552, 1990.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg)   Japanese Journal of Antibiotics. Vol. 35, Pg. 2736, 1982.