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Substance Name: Dihydrocorynantheine
RN: 50439-68-4
UNII: 3O2FX8N0QQ
InChIKey: NMLUOJBSAYAYEM-XPOGPMDLSA-N

Note

  • Isolated from Uncaria rhynchophylla.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C22-H28-N2-O3

Molecular Weight

  • 368.4742
 
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Names and Synonyms

Results Name

  • Dihydrocorynantheine

Name of Substance

  • Dihydrocorynantheine

Synonyms

  • 18,19-Dihydrocorynantheine
  • Dihydrocorynantheine
  • UNII-3O2FX8N0QQ

Systematic Names

  • Corynan-16-carboxylic acid, 16,17-didehydro-17-methoxy-, methyl ester, (16E)-
  • Corynantheine, dihydro- (6CI,7CI)

Registry Numbers

CAS Registry Number

  • 50439-68-4

FDA UNII

  • 3O2FX8N0QQ

System Generated Number

  • 0050439684

Structure Descriptors

InChI

1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17-,20-/m0/s1

InChIKey

NMLUOJBSAYAYEM-XPOGPMDLSA-N

Smiles

CC[C@H]1CN2CCc3c([nH]c4ccccc34)[C@@H]2C[C@@H]1\C(=C/OC)\C(=O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 89mg/kg (89mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 17, 1989.