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Substance Name: Nafiverine dihydrochloride
RN: 5051-16-1
InChIKey: UFCQNKHWIMGGAQ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C34-H38-N2-O4.2Cl-H

Molecular Weight

  • 611.606
 
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Names and Synonyms

Results Name

  • Nafiverine dihydrochloride

Synonyms

  • 1,4-Piperazinediethanol alpha-methyl-1-naphthaleneacetate ester dihydrochloride
  • 2,2'-(1,4-Piperazindiyl)diethylbis(alpha-methyl-1-naphtalinacetat) dihydrochloride
  • N,N'-Bis(2-(alpha-(1-naphthyl)propionyloxy)ethyl)piperazin hydrochlorid
  • N,N'-Di(alpha-(1-naphthyl)propionyloxy-2-ethyl)piperazine dihydrochloride
  • Nafiverine dihydrochloride
  • Nafiverine HCl
  • Naftimepezine

Systematic Name

  • 1-Naphthaleneacetic acid, alpha-methyl-, 1,4-piperazinediyldi-2,1-ethanediyl ester, dihydrochloride

Registry Numbers

CAS Registry Number

  • 5051-16-1

Related Registry Number

  • 5061-22-3 (Parent)

System Generated Number

  • 0005051161

Molecular Formulas

Molecular Formula

  • C34-H38-N2-O4.2Cl-H

Molecular Formula Fragments

  • C34-H38-N2-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C34H38N2O4.2ClH/c1-25(29-15-7-11-27-9-3-5-13-31(27)29)33(37)39-23-21-35-17-19-36(20-18-35)22-24-40-34(38)26(2)30-16-8-12-28-10-4-6-14-32(28)30;;/h3-16,25-26H,17-24H2,1-2H3;2*1H

InChIKey

UFCQNKHWIMGGAQ-UHFFFAOYSA-N

Smiles

c1([C@@H](C(=O)OCCN2CCN(CC2)CCOC([C@@H](c2c3c(cccc3)ccc2)C)=O)C)c2c(cccc2)ccc1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 331mg/kg (331mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 386, 1966.
mouse LD50 intravenous 82mg/kg (82mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 386, 1966.
mouse LD50 oral > 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 386, 1966.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 386, 1966.
rat LD50 oral 5550mg/kg (5550mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 386, 1966.