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Substance Name: Fenspiride [INN]
RN: 5053-06-5
UNII: S983QC7HKM
InChIKey: FVNFBBAOMBJTST-UHFFFAOYSA-N

Note

  • Bronchodilator agent used in asthma.

Molecular Formula

  • C15-H20-N2-O2

Molecular Weight

  • 260.335
 

Classification Codes

  • Anti-Asthmatic Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Fenspiride
  • Fenspiride [INN]

Synonyms

  • BRN 0533332
  • EINECS 225-751-3
  • Fenspirida
  • Fenspirida [INN-Spanish]
  • Fenspiride
  • Fenspiridum
  • Fenspiridum [INN-Latin]
  • Respiride
  • UNII-S983QC7HKM
  • Viarespan

Systematic Names

  • 1-Oxa-3,8-diazaspiro(4,5)decan-2-one, 8-(2-phenylethyl)-
  • Fenspiride

Registry Numbers

CAS Registry Number

  • 5053-06-5

FDA UNII

  • S983QC7HKM

System Generated Number

  • 0005053065

Structure Descriptors

InChI

1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)

InChIKey

FVNFBBAOMBJTST-UHFFFAOYSA-N

Smiles

c1ccc(cc1)CCN2CCC3(CC2)CNC(=O)O3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 210mg/kg (210mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.
guinea pig LD50 oral 260mg/kg (260mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.
mouse LD50 intraperitoneal 230mg/kg (230mg/kg)   Chimica Therapeutica. Vol. 4, Pg. 185, 1969.
mouse LD50 intravenous 106mg/kg (106mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.
mouse LD50 oral 250mg/kg (250mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.
rat LD50 intravenous 122mg/kg (122mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.
rat LD50 oral 980mg/kg (980mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 193, Pg. 111, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.280 (none)   EST
Atmospheric OH Rate Constant 1.15E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.