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Substance Name: Germine
RN: 508-65-6
UNII: TN0Y49N59S
InChIKey: RNPABQVCNAUEIY-GUQYYFCISA-N

Note

  • Alkamine; present in many polyester alkaloids which occur in Veratrum & Zydadenus species; may be used medically as an antihypertensive agent.

Molecular Formula

  • C27-H43-N-O8

Molecular Weight

  • 509.6357
 
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Names and Synonyms

Name of Substance

  • Germine

Synonyms

  • 5-21-13-00706 (Beilstein Handbook Reference)
  • BRN 0099115
  • Cevane-3,4,7,14,15,16,20-heptol, 4,9-epoxy-, (3-beta,4-alpha,7-alpha,5-alpha,16-beta)-
  • Germin
  • Germine
  • NSC 23881
  • UNII-TN0Y49N59S

Systematic Names

  • Cevane-3-beta,4-beta,7-alpha,14,15-alpha,16-beta,20-heptol, 4,9-epoxy-
  • Cevane-3beta,4beta,7alpha,14,15alpha,16beta,20-heptol, 4,9-epoxy- (8CI)

Registry Numbers

CAS Registry Number

  • 508-65-6

FDA UNII

  • TN0Y49N59S

Related Registry Number

  • 5750-58-3 (hydrochloride)

System Generated Number

  • 0000508656

Structure Descriptors

InChI

1S/C27H43NO8/c1-12-4-5-17-24(3,33)19-13(11-28(17)10-12)14-9-25-21(26(14,34)22(32)20(19)31)15(29)8-16-23(25,2)7-6-18(30)27(16,35)36-25/h12-22,29-35H,4-11H2,1-3H3/t12-,13-,14-,15+,16-,17-,18-,19+,20+,21+,22-,23-,24+,25+,26-,27-/m0/s1

InChIKey

RNPABQVCNAUEIY-GUQYYFCISA-N

Smiles

C[C@H]1CC[C@@H]2N(C1)C[C@H]3[C@@H]4C[C@]56O[C@]7(O)[C@@H](O)CC[C@@]5(C)[C@@H]7C[C@@H](O)[C@H]6[C@]4(O)[C@@H](O)[C@H](O)[C@@H]3[C@]2(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo subcutaneous 500mg/kg (500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 189, Pg. 397, 1938.
mouse LD50 subcutaneous > 200mg/kg (200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955.
rat LDLo subcutaneous 2gm/kg (2000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: EXCITEMENT
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 189, Pg. 397, 1938.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 220 deg C   EXP
log P (octanol-water) 1.840 (none)   EST
Atmospheric OH Rate Constant 1.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.