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Substance Name: Pholcodine [INN:BAN]
RN: 509-67-1
UNII: LPP64AWZ7L
InChIKey: GPFAJKDEDBRFOS-FKQDBXSBSA-N

Molecular Formula

  • C23-H30-N2-O4

Molecular Weight

  • 398.5
 

Classification Codes

Classification Codes

  • Analgesics
  • Antitussive Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Respiratory System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Name of Substance

  • Pholcodine
  • Pholcodine [INN:BAN]

Synonyms

  • 3-(2-(4-Morpholinyl)ethyl)morphine
  • 3-Morpholylaethylmorphin
  • 3-Morpholylaethylmorphin [German]
  • 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol
  • beta-Morpholinoethylmorphine
  • Codylin
  • Dia-Tuss
  • EINECS 208-102-9
  • Ethnine Simplex
  • Folcodina
  • Folcodina [INN-Spanish]
  • Folcodina [Spanish]
  • Folcodine
  • Folkodin
  • Folkodin [Czech]
  • Glycodine
  • Hibernyl
  • Homocodeine
  • Memine
  • Morphine, 3-O-(2-morpholinoethyl)-
  • Morphine, O(sup 3)-(2-morpholinoethyl)-
  • Morpholinylethylmorphine
  • Neocodin
  • Neocodine
  • O(sup 3)-(2-Morpholinoethyl)morphine
  • Pectolin
  • Pholcodin
  • Pholcodine
  • Pholcodinum
  • Pholcodinum [INN-Latin]
  • Pholcodinum [Latin]
  • Pholtex
  • Tetrahydro-1,4-oxazinylmethylcodeine
  • Tussokon
  • UNII-LPP64AWZ7L
  • Weifacodine

Systematic Names

  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)-
  • Morpholinylethylmorphine
  • Pholcodine

Superlist Names

  • Adaphol
  • Codisol
  • Copholco
  • DEA No. 9314
  • Lantuss
  • Pholcodine
  • Pholcolin

Registry Numbers

CAS Registry Number

  • 509-67-1

FDA UNII

  • LPP64AWZ7L

System Generated Number

  • 0000509671

Structure Descriptors

InChI

1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1

InChIKey

GPFAJKDEDBRFOS-FKQDBXSBSA-N

Smiles

CN1CC[C@]23[C@H]4Oc5c(OCCN6CCOCC6)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   Therapie. Vol. 7, Pg. 21, 1952.
mouse LD50 intravenous 230mg/kg (230mg/kg)   Therapie. Vol. 7, Pg. 21, 1952.
mouse LD50 oral 1gm/kg (1000mg/kg)   Cesko-Slovenska Farmacie. Vol. 12, Pg. 89, 1963.
mouse LD50 subcutaneous 540mg/kg (540mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958.
rabbit LD50 intravenous 300mg/kg (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 91 deg C   EXP
log P (octanol-water) 0.590 (none)   EST
Water Solubility 2.00E+04 mg/L   EXP
Atmospheric OH Rate Constant 4.21E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.