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Substance Name: Homocamptothecin, (+/-)-
RN: 50906-88-2
UNII: CW4115HGT9
InChIKey: DPUJAXGNZALOPP-UHFFFAOYSA-N

Note

  • A DNA topoisomerase I antagonists, is a semisynthetic analogue of camptothecin (CPT) with a seven-membered beta-hydroxylactone resulting from the insertion of a mehthylene spacer between the alcohol moiety and the carboxyl function of the naturally occurring six-membered alpha-hydroxylactone of CPT.

Molecular Formula

  • C21-H18-N2-O4

Molecular Weight

  • 362.3832
 
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Names and Synonyms

Name of Substance

  • Homocamptothecin
  • Homocamptothecin, (+/-)-

Synonyms

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-(hydroxymethyl)-
  • BN-80765
  • Homocamptothecin
  • Homocamptothecin, (+/-)-
  • Homocamptothecine
  • UNII-CW4115HGT9

Registry Numbers

CAS Registry Number

  • 50906-88-2

FDA UNII

  • CW4115HGT9

System Generated Number

  • 0050906882

Structure Descriptors

InChI

1S/C21H18N2O4/c1-2-21(11-24)15-8-17-18-13(7-12-5-3-4-6-16(12)22-18)9-23(17)19(25)14(15)10-27-20(21)26/h3-8,24H,2,9-11H2,1H3

InChIKey

DPUJAXGNZALOPP-UHFFFAOYSA-N

Smiles

CCC1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccccc5c4)CO