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Substance Name: Mizoribine [INN:JAN]
RN: 50924-49-7
UNII: 4JR41A10VP
InChIKey: HZQDCMWJEBCWBR-UUOKFMHZSA-N

Note

  • Imidazole nucleoside with immunosuppressive activity isolated from culture filtrate of Eupenicillium brefeldianum.

Molecular Formula

  • C9-H13-N3-O6

Molecular Weight

  • 259.2167
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibiotics, Antineoplastic
  • Antimalarials
  • Antineoplastic Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Immunologic Factors
  • Immunosuppressive Agents
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Mizoribine
  • Mizoribine [INN:JAN]

Synonyms

  • 4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate
  • 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide
  • Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide
  • Bredinin
  • Bredinine
  • BRN 4151713
  • HE-69
  • Mizoribina
  • Mizoribina [INN-Spanish]
  • Mizoribine
  • Mizoribinum
  • Mizoribinum [INN-Latin]
  • MZR
  • UNII-4JR41A10VP

Systematic Names

  • 1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl-
  • 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide

Registry Numbers

CAS Registry Number

  • 50924-49-7

FDA UNII

  • 4JR41A10VP

System Generated Number

  • 0050924497

Structure Descriptors

InChI

1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

InChIKey

HZQDCMWJEBCWBR-UUOKFMHZSA-N

Smiles

c1nc(c(n1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 2800mg/kg (2800mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.
mouse LD50 intraperitoneal 5gm/kg (5000mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 275, 1981.
mouse LD50 intravenous 500mg/kg (500mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 275, 1981.
mouse LD50 oral > 4883mg/kg (4883mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.
mouse LD50 subcutaneous > 4883mg/kg (4883mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.
rat LD50 intramuscular > 2800mg/kg (2800mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 3, Pg. 567, 1978.
rat LD50 intravenous 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 3, Pg. 567, 1978.
rat LD50 oral 2847mg/kg (2847mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.
rat LD50 subcutaneous 3795mg/kg (3795mg/kg)   Drugs in Japan Vol. -, Pg. 1148, 1990.