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Substance Name: Nialamide [INN:BAN:NF]
RN: 51-12-7
UNII: T2Q0RYM725
InChIKey: NOIIUHRQUVNIDD-UHFFFAOYSA-N

Note

  • An MAO inhibitor that is used as an antidepressive agent.

Molecular Formula

  • C16-H18-N4-O2

Molecular Weight

  • 298.344
 

Classification Codes

  • Antidepressive Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Monoamine Oxidase Inhibitors
  • Mutation Data
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Nialamide
  • Nialamide [INN:BAN:NF]

MeSH Heading

  • Nialamide

Synonyms

  • 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine
  • 2-(2-(Benzylcarbamoyl)ethyl)hydrazide isonicotinic acid
  • 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid
  • 4-Pyridinecarboxylic acid 2-(3-oxo-3-((phenylmethyl)amino)propyl)hydrazide
  • 5-22-02-00251 (Beilstein Handbook Reference)
  • BEIH
  • BRN 0492941
  • CCRIS 3512
  • Delmoneurina
  • Delmoneurinaesprilisalizina
  • EINECS 200-079-3
  • Espril
  • HSDB 7698
  • Isalizina
  • Isonicotinic acid 2-((2-benzylcarbamoyl)ethyl)hydrazide
  • Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide
  • Mygal
  • N(sup 1)-beta-Benzylcarbamoylethyl-N(sup 2)-isonicotinoylhydrazine
  • N(sup1)-beta-Benzylcarbamoylethyl-N(sup2)-isonicotinoylhydrazine
  • N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide
  • N-Benzyl-beta-(isonicotinoylhydrazine)propionamide
  • N-Benzyl-beta-(isonicotinylhydrazino)propionamide
  • N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazine
  • Nialamid
  • Nialamida
  • Nialamida [INN-Spanish]
  • Nialamide
  • Nialamidum
  • Nialamidum [INN-Latin]
  • Niamid
  • Niamidal
  • Niamide
  • Niaquitil
  • Niazin
  • Novazid
  • NSC 124514
  • Nuredal
  • Nyazin
  • P 1133
  • Psicodisten
  • Surgex
  • UNII-T2Q0RYM725

Systematic Names

  • 4-Pyridinecarboxylic acid, 2-(3-oxo-3-((phenylmethyl)amino)propyl)hydrazide (9CI)
  • Isonicotinic acid 2-((2-benzylcarbamoyl)ethyl)hydrazide
  • Nialamide

Registry Numbers

CAS Registry Number

  • 51-12-7

FDA UNII

  • T2Q0RYM725

System Generated Number

  • 0000051127

Structure Descriptors

InChI

1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

InChIKey

NOIIUHRQUVNIDD-UHFFFAOYSA-N

Smiles

c1(C(NNCCC(NCc2ccccc2)=O)=O)ccncc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Medicina et Pharmacologia Experimentalis. Vol. 16, Pg. 267, 1967.
mouse LD50 intravenous 120mg/kg (120mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
mouse LD50 oral 590mg/kg (590mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
rabbit LD50 intraperitoneal > 150mg/kg (150mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat LD50 intraperitoneal 760mg/kg (760mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 1, Pg. 524, 1959.
rat LD50 oral 1700mg/kg (1700mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 524, 1959.
rat LD50 oral 1700mg/kg (1700mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 1, Pg. 524, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 151.6 deg C   EXP
log P (octanol-water) 0.87 (none)   EXP
Water Solubility 2270 mg/L 25 EST
Vapor Pressure 8.75E-12 mm Hg 25 EST
Henry's Law Constant 1.51E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.18E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.