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Substance Name: Pralidoxime chloride [USAN:USP]
RN: 51-15-0
UNII: 38X7XS076H
InChIKey: HIGSLXSBYYMVKI-UHFFFAOYSA-N

Classification Codes

  • Agricultural Chemical
  • Cholinesterase Reactivator
  • Human Data
  • Insecticide

Molecular Formula

  • C7-H9-N2-O.Cl

Molecular Weight

  • 172.614
 
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Names and Synonyms

Name of Substance

  • Pralidoxime chloride [USAN:USP]

MeSH Heading

  • Pralidoxime

Synonyms

  • 1-Methyl-2-aldoximinopyridinium chloride
  • 1-Methyl-2-formylpyridinium chloride oxime
  • 1-Methyl-2-pyridinium aldoxime chloride
  • 2-(Hydroxyiminomethyl)-1-methylpyridinium chloride
  • 2-Formyl-1-methylpyridinium chloride oxime
  • 2-Formyl-N-methylpyridinium oxime chloride
  • 2-PAM
  • 2-PAM chloride
  • 2-Pyridine aldoxime methyl chloride
  • 2-Pyridine-aldoxime chloride
  • ComboPen
  • EINECS 200-080-9
  • N-Methylpyridine-2-aldoxime chloride
  • N-Methylpyridinium chloride 2-aldoxime
  • N-Methylpyridinium-2-aldoxime chloride
  • N-Metylpyridinium-2-aldoxime chloride
  • NSC 164614
  • Pralidoxime chloride
  • Pralidoxine chloride
  • Protopam chloride
  • Pyridine-2-aldoxime methochloride
  • Pyridinium aldoxime methochloride
  • Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, chloride
  • UNII-38X7XS076H

Systematic Names

  • 2-Hydroxyiminomethyl-1-methylpyridinium chloride
  • Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, chloride
  • Pyridinium, 2-formyl-1-methyl-, chloride, oxime

Mixture Names

  • ATNAA
  • Duodote

Registry Numbers

CAS Registry Number

  • 51-15-0

FDA UNII

  • 38X7XS076H

Related Registry Number

  • 6735-59-7 (Parent)

System Generated Number

  • 0000051150

Molecular Formulas

Molecular Formula

  • C7-H9-N2-O.Cl

Molecular Formula Fragments

  • C7-H9-N2-O
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H

InChIKey

HIGSLXSBYYMVKI-UHFFFAOYSA-N

Smiles

c1([n+](cccc1)C)\C=N\O.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 75mg/kg (75mg/kg)   Fundamental and Applied Toxicology. Vol. 4, Pg. S106, 1984.
guinea pig LD50 intramuscular 168mg/kg (168mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 40, 1970.
human TDLo intravenous 15mg/kg (15mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Archives of Environmental Health. Vol. 15, Pg. 599, 1967.
man TDLo intravenous 14mg/kg (14mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: COMA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 449, 1969.
mouse LD50 intramuscular 100mg/kg (100mg/kg)   Drug and Chemical Toxicology. Vol. 8, Pg. 431, 1985.
mouse LD50 intraperitoneal 155mg/kg (155mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 5, 1964.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 5, 1964.
mouse LD50 oral 4100mg/kg (4100mg/kg)   Journal of Pharmaceutical Sciences. Vol. 53, Pg. 1143, 1964.
rabbit LD50 intravenous 95mg/kg (95mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961.
rat LD50 intramuscular 150mg/kg (150mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 40, 1970.
rat LD50 intravenous 96mg/kg (96mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 40, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 236.5 dec deg C   EXP
log P (octanol-water) -3.440 (none)   EST
Atmospheric OH Rate Constant 1.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.