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Substance Name: Tretamine [INN]
RN: 51-18-3
UNII: F7IY6HZG9D
InChIKey: IUCJMVBFZDHPDX-UHFFFAOYSA-N

Note

  • Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.

Molecular Formula

  • C9-H12-N6

Molecular Weight

  • 204.236
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Insecticide
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Results Name

  • Tretamine [INN]

Name of Substance

  • s-Triazine, 2,4,6-tris(1-aziridinyl)-
  • Tretamine [INN]
  • Triethylenemelamine
  • Triethylenemelamine [NF]

MeSH Heading

  • Triethylenemelamine

Synonyms

  • 1,1',1''-s-Triazine-2,4,6-triyltrisaziridine
  • 1,3,5-Triazine, 2,4,6-tris(1-aziridinyl)-
  • 2,4,6-Tri(ethyleneimino)-1,3,5-triazine
  • 2,4,6-Triethyleneimino-s-triazine
  • 2,4,6-Triethylenimino-1,3,5-triazine
  • 2,4,6-Triethylenimino-s-triazine
  • 2,4,6-Tris(1'-aziridinyl)-1,3,5-triazine
  • 2,4,6-Tris(1-aziridinyl)-s-triazine
  • 2,4,6-Tris(ethyleneimino)-s-triazine
  • 2,4,6-Tris(ethylenimino)-s-triazine
  • 5-26-09-00231 (Beilstein Handbook Reference)
  • AI3-25296
  • Aziridine, 1,1',1''-s-triazine-2,4,6-triyltris-
  • BRN 0242245
  • CCRIS 613
  • DRP 859025
  • EINECS 200-083-5
  • ENT 25,296
  • HSDB 4000
  • M 9500
  • M-9500
  • Melamine, triethylene-
  • NSC 9706
  • Persistol
  • Persistol Ho 1/193
  • Persistol Hoe 1/193
  • R 246
  • R-246
  • SK 1133
  • TAT
  • TEM
  • TEM (cytostatic)
  • Tem-Simes
  • Tretamin
  • Tretamina
  • Tretamina [INN-Spanish]
  • Tretamine
  • Tretaminum
  • Tretaminum [INN-Latin]
  • Triaethylenmelamin
  • Triaethylenmelamin [German]
  • Triamelin
  • Triaziridinyl triazine
  • Triethanomelamine
  • Triethylenemelamine
  • Tris(ethyleneimino)triazine
  • Trisaziridinyltriazine
  • Trisethyleneimino-1,3,5-triazine
  • UNII-F7IY6HZG9D

Systematic Names

  • 1,3,5-Triazine, 2,4,6-tris(1-aziridinyl)-
  • 2,4,6-Tris(1-aziridinyl)-s-triazine
  • s-Triazine, 2,4,6-tris(1-aziridinyl)-
  • Tretamine

Superlist Names

  • 2,4,6-Tris(1-aziridinyl)-s-triazine
  • Triethylenemelamine

Registry Numbers

CAS Registry Number

  • 51-18-3

FDA UNII

  • F7IY6HZG9D

System Generated Number

  • 0000051183

Structure Descriptors

InChI

1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2

InChIKey

IUCJMVBFZDHPDX-UHFFFAOYSA-N

Smiles

c1(N2CC2)nc(N2CC2)nc(n1)N1CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 2870ug/kg (2.87mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LDLo intravenous 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
dog LDLo intravenous 400ug/kg (0.4mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
dog LDLo oral 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
monkey LDLo intravenous 100ug/kg (0.1mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: OTHER CHANGES

BLOOD: LEUKOPENIA
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 202, 1965.
mouse LD50 intramuscular 1500ug/kg (1.5mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 intraperitoneal 2800ug/kg (2.8mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
mouse LD50 oral 15mg/kg (15mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
mouse LD50 subcutaneous 1871ug/kg (1.871mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LDLo intravenous 4mg/kg (4mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

BLOOD: LEUKOPENIA
California Medicine. Vol. 75, Pg. 26, 1951.
quail LD50 oral 133mg/kg (133mg/kg)   Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rat LD50 intracrebral > 400ug/kg (0.4mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 18, Pg. 760, 1966.
rat LD50 intramuscular 1500ug/kg (1.5mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intraperitoneal 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
rat LD50 intraperitoneal 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
rat LD50 intraperitoneal 1mg/kg (1mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
rat LD50 intravenous 1110ug/kg (1.11mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 539, 1956.
rat LD50 oral 13mg/kg (13mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 398, 1950.
rat LDLo unreported 5mg/kg (5mg/kg)   Gann. Japanese Journal of Cancer Research. Vol. 43, Pg. 171, 1952.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.560 (none)   EST
Water Solubility 4.00E+05 mg/L 26 EXP
Vapor Pressure 3.61E-05 mm Hg 25 EST
Henry's Law Constant 1.48E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.94E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.