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Substance Name: Isoproterenol hydrochloride [USP]
RN: 51-30-9
UNII: DIA2A74855
InChIKey: IROWCYIEJAOFOW-UHFFFAOYSA-N

Note

  • Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Molecular Formula

  • C11-H17-N-O3.Cl-H

Molecular Weight

  • 247.7202
 

Classification Codes

  • Bronchodilator
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Isoproterenol hydrochloride [USP]

Synonyms

  • (+-)-Isoprenaline hydrochloride
  • (+-)-Isopropylnoradrenaline hydrochloride
  • (+-)-Isoproterenol hydrochloride
  • 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, hydrochloride
  • 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol hydrochloride
  • Aerolone
  • Aerotrol
  • AI3-52675
  • alpha-(Isopropylaminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride
  • Asthpul
  • CCRIS 5921
  • dl-Isadrine hydrochloride
  • DL-Isoprenaline hydrochloride
  • dl-Isopropylnorepinephrine hydrochloride
  • DL-Isoproterenol hydrochloride
  • EINECS 200-089-8
  • Euspiran
  • Isadrine
  • Isoprenaline chloride
  • Isoprenaline hydrochloride
  • Isoprenaline hydrochloride (VAN)
  • Isopropylarterenol hydrochloride
  • Isopropylnorepinephrine-hydrochloride
  • Isoproterenol HCl
  • Isoproterenol hydrochloride
  • Isoproterenol monohydrochloride
  • Isuprel
  • Isuprel hydrochloride
  • Izadrin
  • l-Isoprenaline hydrochloride
  • NCI-C55630
  • Norisodrine
  • Norisodrine Aerotrol
  • Norisodrine hydrochloride
  • NSC 37745
  • Proternol
  • Saventrine
  • UNII-DIA2A74855
  • Vapo-Iso

Systematic Names

  • 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, hydrochloride
  • Benzenemethanol, 3,4-dihydroxy-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride, (+/-)-
  • Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, hydrochloride
  • Isoprenaline hydrochloride
  • Isoproterenol hydrochloride

Mixture Name

  • Duo-Medihaler

Registry Numbers

CAS Registry Number

  • 51-30-9

FDA UNII

  • DIA2A74855

Other Registry Numbers

  • 1336-89-6
  • 71249-42-8
  • 949-36-0

System Generated Number

  • 0000051309

Molecular Formulas

Molecular Formula

  • C11-H17-N-O3.Cl-H

Molecular Formula Fragments

  • C11-H17-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H

InChIKey

IROWCYIEJAOFOW-UHFFFAOYSA-N

Smiles

Cl.CC(C)NCC(O)c1ccc(O)c(O)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 50mg/kg (50mg/kg)   Drugs in Japan Vol. -, Pg. 119, 1990.
dog LD50 intravenous 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 164, Pg. 290, 1968.
dog LD50 oral 600mg/kg (600mg/kg)   Drugs in Japan Vol. -, Pg. 119, 1990.
dog LD50 oral 600mg/kg (600mg/kg)   Drugs in Japan Vol. -, Pg. 146, 1995.
guinea pig LD50 oral 270mg/kg (270mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 164, Pg. 290, 1968.
guinea pig LD50 subcutaneous 320ug/kg (0.32mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 164, Pg. 290, 1968.
human TDLo oral 250ug/kg (0.25mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 108, 1948.
mouse LC50 inhalation 10gm/m3 (10000mg/m3)   Acta Pharmacologica et Toxicologica. Vol. 40, Pg. 42, 1977.
mouse LD50 intraperitoneal 235mg/kg (235mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 40, Pg. 42, 1977.
mouse LD50 intraperitoneal 450mg/kg (450mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 110, 1947.
mouse LD50 intravenous 65mg/kg (65mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 40, Pg. 42, 1977.
mouse LD50 intravenous 77mg/kg (77mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 501, 1948.
mouse LD50 oral 1260mg/kg (1260mg/kg)   Drugs in Japan Vol. -, Pg. 119, 1990.
mouse LD50 oral 1260mg/kg (1260mg/kg)   Drugs in Japan Vol. -, Pg. 146, 1995.
mouse LD50 subcutaneous 60mg/kg (60mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 subcutaneous 298mg/kg (298mg/kg)   Drugs in Japan Vol. 6, Pg. 74, 1982.
rabbit LD50 intravenous 27mg/kg (27mg/kg)   Drugs in Japan Vol. -, Pg. 119, 1990.
rabbit LD50 intravenous 27mg/kg (27mg/kg)   Drugs in Japan Vol. -, Pg. 146, 1995.
rabbit LD50 oral 3070mg/kg (3070mg/kg)   Drugs in Japan Vol. -, Pg. 119, 1990.
rabbit LD50 oral 3070mg/kg (3070mg/kg)   Drugs in Japan Vol. -, Pg. 146, 1995.
rat LD50 intraperitoneal 128mg/kg (128mg/kg)   Toksikologicheskii Vestnik. Vol. (5), Pg. 40, 1995.
rat LD50 intraperitoneal 303mg/kg (303mg/kg)   Drugs in Japan Vol. 6, Pg. 74, 1982.
rat LD50 intravenous 24040ug/kg (24.04mg/kg)   Drugs in Japan Vol. 6, Pg. 74, 1982.
rat LD50 intravenous 26900ug/kg (26.9mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 627, 1979.
rat LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 501, 1948.
rat LD50 oral 2221mg/kg (2221mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 600ug/kg (0.6mg/kg)   Fundamental and Applied Toxicology. Vol. 1, Pg. 443, 1981.
rat LD50 subcutaneous 435mg/kg (435mg/kg)   Drugs in Japan Vol. 6, Pg. 74, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -2.69E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EST
Vapor Pressure 3.84E-13 mm Hg 25 EST
Henry's Law Constant 9.51E-26 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.23E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.