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Substance Name: Methamphetamine hydrochloride [USP:JAN]
RN: 51-57-0
UNII: 997F43Z9CV
InChIKey: TWXDDNPPQUTEOV-FVGYRXGTSA-N

Note

  • A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.

Molecular Formula

  • C10-H15-N.Cl-H

Molecular Weight

  • 185.6964
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Stimulant (Central)
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Methamphetamine hydrochloride [USP:JAN]

Synonyms

  • (+)-(S)-N,alpha-Dimethylphenethylamine hydrochloride
  • (+)-2-Methylamino-2-phenylpropane hydrochloride
  • (+)-L-Methamphetamine hydrochloride
  • (+)-Methamphetamine chloride
  • (+)-Methamphetamine hydrochloride
  • (+)-Methylamphetamine hydrochloride
  • (+)-N,alpha-Dimethylphenethylamine hydrochloride
  • Adipex
  • AI3-20155
  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (S)-
  • Chestox
  • d-Deoxyephedrine hydrochloride
  • d-Desoxyephedrine hydrochloride
  • d-Methamphetamine hydrochloride
  • d-Methaphetamine hydrochloride
  • d-Methylamphetamine hydrochloride
  • d-N,alpha-Dimethylphenethylamine hydrochloride
  • d-N-Methyl-beta-phenylisopropylamine hydrochloride
  • D-O-E
  • Dee -10
  • Dee -5
  • Dee Dex 10
  • Deofed
  • Des-O-E
  • Des-oxa-D
  • Desepin
  • Desodex
  • Desoxo-5
  • Desoxyfed
  • Desoxyn
  • Desoxyne
  • Destim
  • Desyphed
  • Dexoval
  • Dexstim
  • Dextim
  • DOE
  • Dosoxy
  • Doxyfed
  • Drinalfa
  • Efroxine
  • EINECS 200-106-9
  • Eufodrinal
  • Gerobit
  • Gerovit
  • Hyphet
  • Isophen
  • Isophen (VAN)
  • Madrine
  • Metamphetamine hydrochloride
  • Meth
  • Methampex
  • Methamphetamine HCl
  • Methamphetamine hydrochloride
  • Methamphetaminium chloride
  • Methaphetaminium chloride
  • Methedrine hydrochloride
  • Methylamphetamine hydrochloride
  • Methylisomyn
  • N-Methylamphetamine hydrochloride
  • Norodin hydrochloride
  • NSC 169505
  • Obedrin-LA
  • Pervitin
  • Phenethylamine, N,alpha-dimethyl-, hydrochloride, (+)-
  • Philopon
  • S-(+)-Methamphetamine hydrochloride
  • Semoxydrine hydrochloride
  • Soxysympamine
  • Syndrox
  • Tonedron
  • UNII-997F43Z9CV

Systematic Names

  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride (1:1), (alphaS)-
  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (alphaS)-
  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (S)- (9CI)
  • Methamphetamine hydrochloride
  • Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

Registry Numbers

CAS Registry Number

  • 51-57-0

FDA UNII

  • 997F43Z9CV

Other Registry Numbers

  • 51176-61-5
  • 6823-88-7

System Generated Number

  • 0000051570

Molecular Formulas

Molecular Formula

  • C10-H15-N.Cl-H

Molecular Formula Fragments

  • C10-H15-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

InChIKey

TWXDDNPPQUTEOV-FVGYRXGTSA-N

Smiles

Cl.CN[C@@H](C)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 90mg/kg (90mg/kg)   Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 351, 1954.
mammal (species unspecified) LD50 intravenous 9500ug/kg (9.5mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2901868,
mammal (species unspecified) LD50 subcutaneous 14mg/kg (14mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2901868,
man TCLo inhalation 28mg/kg (28mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: EXCITEMENT
Veterinary and Human Toxicology. Vol. 41, Pg. 28, 1999.
mouse LD50 intraperitoneal 15mg/kg (15mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 346, 1972.
mouse LD50 intravenous 6300ug/kg (6.3mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02170,
mouse LD50 subcutaneous 7560ug/kg (7.56mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.
rat LD50 subcutaneous 10930ug/kg (10.93mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 253, Pg. 466, 1990.