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Substance Name: Dopamine [INN:BAN]
RN: 51-61-6
UNII: VTD58H1Z2X
InChIKey: VYFYYTLLBUKUHU-UHFFFAOYSA-N

Note

  • One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Molecular Formula

  • C8-H11-N-O2

Molecular Weight

  • 153.18
 

Classification Codes

  • Autonomic Agents
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Dopamine Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Protective Agents
  • Reproductive Effect
  • Sympathomimetics

Names and Synonyms

Name of Substance

  • Dopamine
  • Dopamine [INN:BAN]

MeSH Heading

  • Dopamine

Synonyms

  • 1,2-Benzenediol, 4-(2-aminoethyl)-
  • 2-(3,4-Dihydroxyphenyl)ethylamine
  • 3,4-Dihydroxyphenethylamine
  • 3,4-Dihydroxyphenylethylamine
  • 3-Hydroxytyramine
  • 4-(2-Aminoethyl)-1,2-benzenediol
  • 4-(2-Aminoethyl)catechol
  • 4-(2-Aminoethyl)pyrocatechol
  • alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
  • ASL 279
  • DA
  • Dopamin
  • Dopamina
  • Dopamina [INN-Spanish]
  • Dopamine
  • Dopaminum
  • Dopaminum [INN-Latin]
  • EINECS 200-110-0
  • HSDB 3068
  • Hydroxytyramin
  • KW-3-060
  • NSC 173182
  • Oxytyramine
  • Pyrocatechol, 4-(2-aminoethyl)-
  • UNII-VTD58H1Z2X

Systematic Names

  • 1,2-Benzenediol, 4-(2-aminoethyl)-
  • 1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
  • Dopamine
  • Pyrocatechol, 4-(2-aminoethyl)-

Registry Numbers

CAS Registry Number

  • 51-61-6

FDA UNII

  • VTD58H1Z2X

Related Registry Number

  • 62-31-7 (hydrochloride)

System Generated Number

  • 0000051616

Structure Descriptors

InChI

InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2

InChIKey

VYFYYTLLBUKUHU-UHFFFAOYSA-N

Smiles

NCCc1ccc(O)c(O)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 1120mg/kg (1120mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 42, 1990.
mouse LD50 intracervical 74mg/kg (74mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980.
mouse LD50 intraperitoneal 950mg/kg (950mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974.
mouse LD50 intravenous 59mg/kg (59mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: HEMORRHAGE		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974.
rat LD50 intraperitoneal 163mg/kg (163mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 128 deg C   EXP
pKa Dissociation Constant 8.93 (none)   EXP
log P (octanol-water) -0.98 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EST
Vapor Pressure 2.57E-05 mm Hg 25 EST
Henry's Law Constant 8.79E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.01E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.