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Substance Name: Dopamine [INN:BAN]
RN: 51-61-6
UNII: VTD58H1Z2X
InChIKey: VYFYYTLLBUKUHU-UHFFFAOYSA-N
Note
- One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Molecular Formula
- C8-H11-N-O2
Molecular Weight
- 153.18
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- Toxicity
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Classification Codes
- Autonomic Agents
- Cardiotonic Agents
- Cardiovascular Agents
- Dopamine Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Protective Agents
- Reproductive Effect
- Sympathomimetics
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Names and Synonyms
Name of Substance
- Dopamine
- Dopamine [INN:BAN]
MeSH Heading
- Dopamine
Synonyms
- 1,2-Benzenediol, 4-(2-aminoethyl)-
- 2-(3,4-Dihydroxyphenyl)ethylamine
- 3,4-Dihydroxyphenethylamine
- 3,4-Dihydroxyphenylethylamine
- 3-Hydroxytyramine
- 4-(2-Aminoethyl)-1,2-benzenediol
- 4-(2-Aminoethyl)catechol
- 4-(2-Aminoethyl)pyrocatechol
- alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
- ASL 279
- DA
- Dopamin
- Dopamina
- Dopamina [INN-Spanish]
- Dopamine
- Dopaminum
- Dopaminum [INN-Latin]
- EINECS 200-110-0
- HSDB 3068
- Hydroxytyramin
- KW-3-060
- NSC 173182
- Oxytyramine
- Pyrocatechol, 4-(2-aminoethyl)-
- UNII-VTD58H1Z2X
Systematic Names
- 1,2-Benzenediol, 4-(2-aminoethyl)-
- 1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
- Dopamine
- Pyrocatechol, 4-(2-aminoethyl)-
Registry Numbers
CAS Registry Number
- 51-61-6
FDA UNII
- VTD58H1Z2X
Related Registry Number
- 62-31-7 (hydrochloride)
System Generated Number
- 0000051616
Structure Descriptors
InChI
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2InChIKey
VYFYYTLLBUKUHU-UHFFFAOYSA-NSmiles
NCCc1ccc(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | unreported | 1120mg/kg (1120mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 42, 1990. | |
mouse | LD50 | intracervical | 74mg/kg (74mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980. |
mouse | LD50 | intraperitoneal | 950mg/kg (950mg/kg) | BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974. |
mouse | LD50 | intravenous | 59mg/kg (59mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: HEMORRHAGE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974. |
rat | LD50 | intraperitoneal | 163mg/kg (163mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 128 | deg C | EXP | |
pKa Dissociation Constant | 8.93 | (none) | EXP | |
log P (octanol-water) | -0.98 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 25 | EST |
Vapor Pressure | 2.57E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 8.79E-15 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 9.01E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.