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Substance Name: Tremorine
RN: 51-73-0
UNII: U817VZ1URQ
InChIKey: JSUAJTLKVREZHV-UHFFFAOYSA-N

Molecular Formula

  • C12-H20-N2

Molecular Weight

  • 192.304
 
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Names and Synonyms

Name of Substance

  • Tremorine

MeSH Heading

  • Tremorine

Synonyms

  • 1,4-Dipyrrolidine-2-butyne
  • 1,4-Dipyrrolidino-2-butyne
  • 1,4-Dipyrrolidinyl-2-butyne
  • 2-Butyne, 1,4-bis(1-pyrrolidinyl)-
  • 5-20-01-00421 (Beilstein Handbook Reference)
  • Biofermin
  • BRN 0006119
  • Dipyrrolidine, 1,1'-(2-butynylene)-
  • NSC 407428
  • Tremorin
  • Tremorine
  • UNII-U817VZ1URQ

Systematic Names

  • Pyrrolidine, 1,1'-(2-butyne-1,4-diyl)bis-
  • Pyrrolidine, 1,1'-(2-butynylene)di-

Registry Numbers

CAS Registry Number

  • 51-73-0

FDA UNII

  • U817VZ1URQ

System Generated Number

  • 0000051730

Structure Descriptors

InChI

1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2

InChIKey

JSUAJTLKVREZHV-UHFFFAOYSA-N

Smiles

C1CCN(C1)CC#CCN2CCCC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LDLo subcutaneous 5mg/kg (5mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 447, 1962.
mouse LD50 intraperitoneal 25mg/kg (25mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971.
mouse LD50 intravenous 112mg/kg (112mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#12070,
mouse LD50 subcutaneous 58mg/kg (58mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: TREMOR
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56(3), Pg. 83S, 1960.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 1.740 (none)   EST
Atmospheric OH Rate Constant 2.07E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.