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Substance Name: Histamine phosphate [USP]
RN: 51-74-1
UNII: QWB37T4WZZ
InChIKey: ZHIBQGJKHVBLJJ-UHFFFAOYSA-N

Note

  • An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Molecular Formula

  • C5-H9-N3.2H3-O4-P

Molecular Weight

  • 307.1345
 

Classification Codes

  • Histamine Agents
  • Neurotransmitter Agents
  • Reproductive Effect
  • Stimulant (Gastric Secretory)
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Names and Synonyms

Name of Substance

  • Histamine phosphate
  • Histamine phosphate [USP]

Synonyms

  • 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
  • 4-(2-Aminoethyl)imidazole di-acid phosphate
  • EINECS 200-118-4
  • Histamine acid phosphate
  • Histamine biphosphate
  • Histamine dihydrogen phosphate
  • Histamine diphosphate
  • Histamine phosphate
  • Histamine phosphate (1:2)
  • Histamine positive
  • UNII-QWB37T4WZZ

Systematic Names

  • 1H-Imidazole-4-ethanamine, phosphate (1:2)
  • 2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

Registry Numbers

CAS Registry Number

  • 51-74-1

FDA UNII

  • QWB37T4WZZ

Other Registry Numbers

  • 53623-99-7
  • 74-56-6

System Generated Number

  • 0000051741

Molecular Formulas

Molecular Formula

  • C5-H9-N3.2H3-O4-P

Molecular Formula Fragments

  • C5-H9-N3
  • COMPONENT
  • H3-O4-P

Structure Descriptors

InChI

InChI=1S/C5H9N3.2H3O4P/c6-2-1-5-3-7-4-8-5;2*1-5(2,3)4/h3-4H,1-2,6H2,(H,7,8);2*(H3,1,2,3,4)

InChIKey

ZHIBQGJKHVBLJJ-UHFFFAOYSA-N

Smiles

NCCc1c[nH]cn1.OP(=O)(O)O.OP(=O)(O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 608ug/kg (0.608mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Journal of Pharmaceutical Sciences. Vol. 57, Pg. 1543, 1968.
guinea pig LDLo parenteral 746ug/kg (0.746mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1574, 1970.
mouse LD50 intraperitoneal 913mg/kg (913mg/kg)   Journal of Pharmaceutical Sciences. Vol. 59, Pg. 1659, 1970.
mouse LD50 intravenous 333mg/kg (333mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 90, Pg. 726, 1955.
mouse LD50 oral 807mg/kg (807mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 122, Pg. 685, 1966.
rabbit LD50 intravenous 2763ug/kg (2.763mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 299, 1942.
rabbit LDLo parenteral 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.
rat LD50 intraperitoneal 1781mg/kg (1781mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.
rat LDLo intravenous 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.