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Substance Name: Cystamine
RN: 51-85-4
UNII: R110LV8L02
InChIKey: APQPRKLAWCIJEK-UHFFFAOYSA-N

Note

  • A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.

Molecular Formula

  • C4-H12-N2-S2

Molecular Weight

  • 152.285
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Indicators and Reagents
  • Mutation Data
  • Protective Agents
  • Radiation-Protective Agents
  • Sulfhydryl Reagents
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Names and Synonyms

Name of Substance

  • Cystamine

MeSH Heading

  • Cystamine

Synonyms

  • 1591 L
  • 2,2'-Dithiobis(ethylamine)
  • 2-Mercaptoethylamine (oxidized)
  • 4-04-00-01577 (Beilstein Handbook Reference)
  • Becaptan disulfure
  • Becaptan disulfure [French]
  • beta,beta'-Diaminodiethyl disulfide
  • beta-Mercaptoethylamine disulfide
  • Bis(beta-aminoethyl)disulfide
  • BRN 1736027
  • Cystamine
  • Cysteinamine disulfide
  • Cystinamin
  • Cystinamin [German]
  • Cystineamine
  • Decarboxycystine
  • EINECS 200-129-4
  • Mercamine disulfide
  • UNII-R110LV8L02

Systematic Names

  • 2,2'-Dithiobis(ethylamine)
  • Ethanamine, 2,2'-dithiobis-
  • Ethylamine, 2,2'-dithiobis-

Registry Numbers

CAS Registry Number

  • 51-85-4

FDA UNII

  • R110LV8L02

Related Registry Numbers

  • 101418-33-1 (calcium salt)
  • 16214-16-7 (sulfate)
  • 17173-68-1 (hydrochloride)
  • 21198-98-1 (di-hydrobromide)
  • 56-17-7 (di-hydrochloride)

System Generated Number

  • 0000051854

Structure Descriptors

InChI

1S/C4H12N2S2/c5-1-3-7-8-4-2-6/h1-6H2

InChIKey

APQPRKLAWCIJEK-UHFFFAOYSA-N

Smiles

S(SCCN)CCN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 200mg/kg (200mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: GENERAL ANESTHETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.
guinea pig LDLo subcutaneous 300mg/kg (300mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.
mouse LD50 intraperitoneal 220mg/kg (220mg/kg)   Radiobiologia, Radiotherapia. Vol. 19, Pg. 593, 1978.
mouse LD50 subcutaneous 214mg/kg (214mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 108, 1957.
rat LD50 intramuscular 96mg/kg (96mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Sbornik Vedeckych Praci Lekarske Fakulty Univerzity Karlovy v Hradci Kralove. Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove. Vol. 24, Pg. 541, 1981.
rat LD50 intraperitoneal 99mg/kg (99mg/kg)   Sbornik Vedeckych Praci Lekarske Fakulty Univerzity Karlovy v Hradci Kralove. Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove. Vol. 24, Pg. 541, 1981.
rat LDLo subcutaneous 150mg/kg (150mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.