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Substance Name: Tiapride hydrochloride [JAN]
RN: 51012-33-0
UNII: 25N106WEDO
InChIKey: OTFDPNXIVHBTKW-UHFFFAOYSA-N

Note

  • Benzamide derivative with dopamine antagonist actions similar to SULPIRIDE. It has been used as an antipsychotic and in the treatment of various movement disorders.

Molecular Formula

  • C15-H24-N2-O4-S.Cl-H

Molecular Weight

  • 364.892
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Tiapride hydrochloride
  • Tiapride hydrochloride [JAN]

Synonyms

  • EINECS 256-908-4
  • N-(2-(Diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamide hydrochloride
  • N-(2-(Diethylamino)ethyl)-5-(methylsulfonyl)-o-anisamide hydrochloride
  • Tiapride HCl
  • Tiapride hydrochloride
  • UNII-25N106WEDO

Systematic Names

  • Benzamide, N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-, monohydrochloride
  • N-(2-(Diethylamino)ethyl)-2-methoxy-5-(methylsulphonyl)benzamide monohydrochloride

Registry Numbers

CAS Registry Number

  • 51012-33-0

FDA UNII

  • 25N106WEDO

Related Registry Number

  • 51012-32-9 (Parent)

System Generated Number

  • 0051012330

Molecular Formulas

Molecular Formula

  • C15-H24-N2-O4-S.Cl-H

Molecular Formula Fragments

  • C15-H24-N2-O4-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H

InChIKey

OTFDPNXIVHBTKW-UHFFFAOYSA-N

Smiles

c1(c(ccc(c1)S(C)(=O)=O)OC)C(NCC[NH+](CC)CC)=O.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 240mg/kg (240mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
mouse LD50 intraperitoneal 336mg/kg (336mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
mouse LD50 intravenous 189mg/kg (189mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
mouse LD50 oral 1340mg/kg (1340mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
mouse LD50 subcutaneous 755mg/kg (755mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
rat LD50 intraperitoneal 421mg/kg (421mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
rat LD50 intravenous 254mg/kg (254mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
rat LD50 oral 4840mg/kg (4840mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
rat LD50 subcutaneous 1130mg/kg (1130mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.