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Substance Name: Flurbiprofen [USAN:USP:INN:BAN:JAN]
RN: 5104-49-4
UNII: 5GRO578KLP
InChIKey: SYTBZMRGLBWNTM-UHFFFAOYSA-N
Note
- An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
Molecular Formula
- C15-H13-F-O2
Molecular Weight
- 244.2637
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Central Nervous System Agents
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Flurbiprofen
- Flurbiprofen [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Flurbiprofen
Synonyms
- (+-)-2-(2-Fluoro-4-biphenylyl)propionic acid
- (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
- (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, (+-)-
- 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid
- 3-Fluoro-4-phenylhydratropic acid
- Adofeed
- Ansaid
- Antadys
- BTS 18,322
- BTS 18322
- CCRIS 3708
- EINECS 225-827-6
- EINECS 257-262-6
- Flurbiprofen
- Flurbiprofene
- Flurbiprofene [INN-French]
- Flurbiprofeno
- Flurbiprofeno [INN-Spanish]
- Flurbiprofenum
- Flurbiprofenum [INN-Latin]
- FP 70
- Froben
- NSC 757037
- U 27,182
- U 27182
- U-27,182
- UNII-5GRO578KLP
Systematic Names
- (1)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid
- (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, (+-)-
- 4-Biphenylacetic acid, 2-fluoro-alpha-methyl-
- Flurbiprofen
Superlist Name
- Flurbiprofen
Registry Numbers
CAS Registry Number
- 5104-49-4
FDA UNII
- 5GRO578KLP
Other Registry Number
- 51543-38-5
System Generated Number
- 0005104494
Structure Descriptors
InChI
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)InChIKey
SYTBZMRGLBWNTM-UHFFFAOYSA-NSmiles
CC(C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 10mg/kg (10mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
man | TDLo | oral | 30mg/kg/2W-I (30mg/kg) | British Medical Journal. Vol. 4, Pg. 496, 1974. | |
man | TDLo | oral | 30mg/kg/2W-I (30mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: HEADACHE | British Medical Journal. Vol. 4, Pg. 496, 1974. |
mouse | LD50 | intraperitoneal | 890mg/kg (890mg/kg) | Russian Pharmacology and Toxicology Vol. 49, Pg. 98, 1986. | |
mouse | LD50 | intravenous | > 385mg/kg (385mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: CHANGES IN REFRACTION: EYE | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
mouse | LD50 | oral | 640mg/kg (640mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
mouse | LD50 | subcutaneous | 550mg/kg (550mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
rabbit | LD50 | oral | 290mg/kg (290mg/kg) | Drugs in Japan Vol. 6, Pg. 707, 1982. | |
rat | LD50 | intraperitoneal | 108mg/kg (108mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
rat | LD50 | oral | 117mg/kg (117mg/kg) | BLOOD: NORMOCYTIC ANEMIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
rat | LD50 | subcutaneous | 100mg/kg (100mg/kg) | BLOOD: NORMOCYTIC ANEMIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2641, 1975. |
women | TDLo | oral | 14mg/kg/7D-I (14mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Internal Medicine. Vol. 112, Pg. 550, 1990. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 110-111 | deg C | EXP | |
log P (octanol-water) | 4.16 | (none) | EXP | |
Water Solubility | 8 | mg/L | 22 | EXP |
Vapor Pressure | 1.96E-06 | mm Hg | 25 | EST |
Henry's Law Constant | 5.26E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 8.78E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.