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Substance Name: Dihydroergotamine [INN:BAN]
RN: 511-12-6
UNII: 436O5HM03C
InChIKey: LUZRJRNZXALNLM-JGRZULCMSA-N
Note
- A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Molecular Formula
- C33-H37-N5-O5
Molecular Weight
- 583.685
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Antiviral (COVID-19)
- Cardiovascular Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Agonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Vasoconstrictor Agents
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Names and Synonyms
Name of Substance
- Dihydroergotamine
- Dihydroergotamine [INN:BAN]
MeSH Heading
- Dihydroergotamine
Synonyms
- 9,10-Dihydroergotamine
- BRN 5720196
- Dehydroergotamine
- DHE
- Dihidroergotamina
- Dihidroergotamina [INN-Spanish]
- Dihydroergotamine
- Dihydroergotaminum
- Dihydroergotaminum [INN-Latin]
- Diidroergotamina
- Diidroergotamina [DCIT]
- EINECS 208-123-3
- Ergotamine, 9,10-dihydro-
- Levadex
- MAP 0004
- MAP0004
- UNII-436O5HM03C
Systematic Names
- Dihydroergotamine
- Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-
Registry Numbers
CAS Registry Number
- 511-12-6
FDA UNII
- 436O5HM03C
Other Registry Numbers
- 11019-70-8
- 1381-00-6
- 17680-45-4
- 26913-96-2
- 29087-32-9
- 409-63-2
- 47842-41-1
- 5965-22-0
- 6016-53-1
- 7762-45-0
- 98302-70-6
Related Registry Number
- 6190-39-2 (mesylate)
System Generated Number
- 0000511126
Structure Descriptors
InChI
InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1InChIKey
LUZRJRNZXALNLM-JGRZULCMSA-NSmiles
CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | subcutaneous | 68mg/kg (68mg/kg) | Schweizerische Medizinische Wochenschrift. Vol. 76, Pg. 1254, 1946. | |
mouse | LD50 | intravenous | 118mg/kg (118mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 317, 1956. | |
mouse | LD50 | oral | > 8gm/kg (8000mg/kg) | French Medicament Patent Document. Vol. #2292M, | |
mouse | LD50 | subcutaneous | 80mg/kg (80mg/kg) | Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. | |
rabbit | LD50 | intravenous | 25mg/kg (25mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 317, 1956. | |
rabbit | LD50 | oral | > 8gm/kg (8000mg/kg) | French Medicament Patent Document. Vol. #2292M, |