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Substance Name: Somatostatin
RN: 51110-01-1
InChIKey: NHXLMOGPVYXJNR-UHFFFAOYSA-N
Note
- A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Molecular Formula
- Unspecified
Molecular Weight
- 1637.9
Classification Codes
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms
MeSH Heading
- Somatostatin
Synonyms
- Aminopan
- AY 24910
- CCRIS 7071
- EINECS 256-969-7
- Growth hormone release-inhibiting factor
- Growth hormone release-inhibiting hormone
- Panhibin
- Somatostatin
- Somatostatin 14
- Somatostatin-14
- Somatotropin release-inhibiting factor
- Somatotropin release-inhibiting hormone
- Somiaton
- SRIF
- SRIF 14
Systematic Name
- Somatostatin
Registry Numbers
CAS Registry Number
- 51110-01-1
Other Registry Numbers
- 52500-64-8
- 53126-12-8
- 56451-83-3
Related Registry Number
- 38916-34-6 (sheep)
System Generated Number
- 0051110011
Structure Descriptors
InChI
InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)InChIKey
NHXLMOGPVYXJNR-UHFFFAOYSA-NSmiles
CC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology Letters. Vol. 17, Pg. 145, 1983. |
rat | LD50 | intravenous | 21mg/kg (21mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology Letters. Vol. 17, Pg. 145, 1983. |