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Substance Name: Somatostatin
RN: 51110-01-1
InChIKey: NHXLMOGPVYXJNR-UHFFFAOYSA-N

Note

  • A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

Molecular Formula

  • Unspecified

Molecular Weight

  • 1637.9
 

Classification Codes

  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

MeSH Heading

  • Somatostatin

Synonyms

  • Aminopan
  • AY 24910
  • CCRIS 7071
  • EINECS 256-969-7
  • Growth hormone release-inhibiting factor
  • Growth hormone release-inhibiting hormone
  • Panhibin
  • Somatostatin
  • Somatostatin 14
  • Somatostatin-14
  • Somatotropin release-inhibiting factor
  • Somatotropin release-inhibiting hormone
  • Somiaton
  • SRIF
  • SRIF 14

Systematic Name

  • Somatostatin

Registry Numbers

CAS Registry Number

  • 51110-01-1

Other Registry Numbers

  • 52500-64-8
  • 53126-12-8
  • 56451-83-3

Related Registry Number

  • 38916-34-6 (sheep)

System Generated Number

  • 0051110011

Structure Descriptors

InChI

1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)

InChIKey

NHXLMOGPVYXJNR-UHFFFAOYSA-N

Smiles

c12c(C[C@@H]3NC([C@@H](Cc4ccccc4)NC([C@@H](Cc4ccccc4)NC([C@@H](NC([C@@H](NC([C@@H](CSSC[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC3=O)CCCCN)=O)[C@@H](C)O)=O)Cc3ccccc3)=O)[C@@H](C)O)=O)CO)=O)C(O)=O)NC(CNC([C@@H](C)N)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)c[nH]c1cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 33mg/kg (33mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toxicology Letters. Vol. 17, Pg. 145, 1983.
rat LD50 intravenous 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS		 Toxicology Letters. Vol. 17, Pg. 145, 1983.