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Substance Name: Denotivir [INN]
RN: 51287-57-1
UNII: W656S9I00W
InChIKey: ZPBLNADJHWHOEP-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H14-Cl-N3-O2-S

Molecular Weight

  • 371.847
 
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Names and Synonyms

Name of Substance

  • 5-(Benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
  • Denotivir [INN]

Synonyms

  • 3-Methyl-5-benzoylaminoisothiazole-4-carboxylic acid p-chlorophenylamide
  • 5-(Benzoylamino)-N-(p-chlorophenyl)-3-methyl-4-isothiazolecarboxamide
  • Denotivir
  • ITCL
  • p-Chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic acid
  • T-15
  • UNII-W656S9I00W
  • Wratizolin

Systematic Names

  • 4-Isothiazolecarboxamide, 5-(benzoylamino)-N-(p-chlorophenyl)-3-methyl-
  • 5-Benzamido-4'-chloro-3-methyl-4-isothiazolecarboxanilide

Registry Numbers

CAS Registry Number

  • 51287-57-1

FDA UNII

  • W656S9I00W

System Generated Number

  • 0051287571

Structure Descriptors

InChI

1S/C18H14ClN3O2S/c1-11-15(17(24)20-14-9-7-13(19)8-10-14)18(25-22-11)21-16(23)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)(H,21,23)

InChIKey

ZPBLNADJHWHOEP-UHFFFAOYSA-N

Smiles

c1(c(NC(c2ccccc2)=O)snc1C)C(Nc1ccc(Cl)cc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 219mg/kg (219mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archivum Immunologiae et Therapiae Experimentalis. Vol. 28, Pg. 393, 1980.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 28, Pg. 393, 1980.
rat LD50 intraperitoneal 330mg/kg (330mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archivum Immunologiae et Therapiae Experimentalis. Vol. 28, Pg. 393, 1980.
rat LD50 oral > 3gm/kg (3000mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 28, Pg. 393, 1980.