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Substance Name: Sparfosic Acid [INN]
RN: 51321-79-0
UNII: 78QVZ7RG8L
InChIKey: ZZKNRXZVGOYGJT-VKHMYHEASA-N

Note

  • Inhibitor of aspartate transcarbamylase; bisubstrate ligand.

Molecular Formula

  • C6-H10-N-O8-P

Molecular Weight

  • 255.118
 

Classification Codes

  • Anti-Infective Agents
  • Antimetabolites
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Noxae
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sparfosic acid
  • Sparfosic Acid [INN]

Synonyms

  • Acide sparfosique
  • Acide sparfosique [INN-French]
  • Acido sparfosico
  • Acido sparfosico [INN-Spanish]
  • Acidum sparfosicum
  • Acidum sparfosicum [INN-Latin]
  • N-(Phosphonacetyl)-L-aspartic acid
  • N-(Phosphonoacetyl)-asparaginsaeure
  • N-Phosphonacetyl-L-aspartate
  • NSC-224131
  • PALA
  • Phosphonacetyl-L-aspartic acid
  • Sparfosic Acid
  • UNII-78QVZ7RG8L

Systematic Names

  • L-Aspartic acid, N-(phosphonoacetyl)-
  • N-(Phosphonoacetyl)-L-aspartic acid

Registry Numbers

CAS Registry Number

  • 51321-79-0

FDA UNII

  • 78QVZ7RG8L

Related Registry Number

  • 60342-56-5 (tetra-hydrochloride salt)

System Generated Number

  • 0051321790

Structure Descriptors

InChI

1S/C6H10NO8P/c8-4(2-16(13,14)15)7-3(6(11)12)1-5(9)10/h3H,1-2H2,(H,7,8)(H,9,10)(H,11,12)(H2,13,14,15)/t3-/m0/s1

InChIKey

ZZKNRXZVGOYGJT-VKHMYHEASA-N

Smiles

N([C@@H](CC(O)=O)C(O)=O)C(CP(O)(O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 862mg/kg (862mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Drugs of the Future. Vol. 6, Pg. 152, 1981.
mouse LD50 unreported 4gm/kg (4000mg/kg)   Cancer Research. Vol. 46, Pg. 2703, 1986.