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Substance Name: Tizanidine [INN:BAN]
RN: 51322-75-9
UNII: 6AI06C00GW
InChIKey: XFYDIVBRZNQMJC-UHFFFAOYSA-N

Molecular Formula

  • C9-H8-Cl-N5-S

Molecular Weight

  • 253.716
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-2 Receptor Agonists
  • Adrenergic alpha-Agonists
  • Analgesics
  • Anticonvulsants
  • Autonomic Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Neurotransmitter Agents
  • Parasympatholytics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Tizanidine
  • Tizanidine [INN:BAN]

Synonyms

  • 2,1,3-Benzothiadiazole-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
  • BRN 0618691
  • Sirdalud
  • Ternelin
  • Tizanidina
  • Tizanidina [INN-Spanish]
  • Tizanidine
  • Tizanidinum
  • Tizanidinum [INN-Latin]
  • UNII-6AI06C00GW

Systematic Names

  • 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
  • 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-

Registry Numbers

CAS Registry Number

  • 51322-75-9

FDA UNII

  • 6AI06C00GW

Related Registry Number

  • 64461-82-1 (mono-hydrochloride)

System Generated Number

  • 0051322759

Structure Descriptors

InChI

1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)

InChIKey

XFYDIVBRZNQMJC-UHFFFAOYSA-N

Smiles

c12c(NC=3NCCN3)c(ccc1nsn2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 235mg/kg (235mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 793, 1980.
rat LD50 oral 600mg/kg (600mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 793, 1980.