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Substance Name: Budesonide [USAN:INN:BAN:JAN]
RN: 51333-22-3
UNII: Q3OKS62Q6X
InChIKey: VOVIALXJUBGFJZ-KWVAZRHASA-N

Note

  • A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.

Molecular Formula

  • C25-H34-O6

Molecular Weight

  • 430.5376
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Asthmatic Agents
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Respiratory System Agents

Names and Synonyms

Name of Substance

  • Budesonide
  • Budesonide [USAN:INN:BAN:JAN]

MeSH Heading

  • Budesonide

Synonyms

  • (11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • (RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
  • 16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
  • Bidien
  • Budecort Inhaler
  • Budeson
  • Budesonide
  • Budesonido
  • Budesonido [INN-Spanish]
  • Budesonidum
  • Budesonidum [INN-Latin]
  • CCRIS 5230
  • Cortivent
  • EINECS 257-139-7
  • Entocort
  • Entocort EC
  • Fvolir
  • HSDB 8279
  • Micronyl
  • Preferid
  • Pulmicort
  • Pulmicort Flexhaler
  • Pulmicort Respules
  • Respules
  • Rhinocort
  • Rhinocort Allergy
  • Rhinocort alpha
  • Rhinocort aqua
  • S 1320
  • Spirocort
  • Uceris
  • UNII-Q3OKS62Q6X

Systematic Names

  • Budesonide
  • Pregna-1,4-diene-3,20-dione, 16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11-beta,16-alpha)-
  • Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 51333-22-3

FDA UNII

  • Q3OKS62Q6X

System Generated Number

  • 0051333223

Structure Descriptors

InChI

1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1

InChIKey

VOVIALXJUBGFJZ-KWVAZRHASA-N

Smiles

CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous 173mg/kg (173mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
man TCLo inhalation 34ug/kg (0.034mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Australian and New Zealand Journal of Medicine. Vol. 22, Pg. 511, 1992.
mouse LD50 intraperitoneal 179mg/kg (179mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 intravenous 124mg/kg (124mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 oral 4750mg/kg (4750mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 subcutaneous 53600ug/kg (53.6mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 intraperitoneal 138mg/kg (138mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 intravenous 98900ug/kg (98.9mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 oral > 3200mg/kg (3200mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 subcutaneous 58400ug/kg (58.4mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 226 dec deg C   EXP
log P (octanol-water) 2.180 (none)   EST
Atmospheric OH Rate Constant 1.28E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.