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Substance Name: Metoprolol [USAN:INN:BAN]
RN: 51384-51-1
UNII: GEB06NHM23
InChIKey: IUBSYMUCCVWXPE-UHFFFAOYSA-N
Note
- A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Molecular Formula
- C15-H25-N-O3
Molecular Weight
- 267.3665
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Antagonists
- Adrenergic beta-1 Receptor Antagonists
- Adrenergic beta-Antagonists
- Anti-Adrenergic (beta-Receptor)
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Autonomic Agents
- Cardiovascular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympatholytics
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Names and Synonyms
Name of Substance
- Metoprolol
- Metoprolol [USAN:INN:BAN]
MeSH Heading
- Metoprolol
Synonyms
- (+/-)-1-(Isopropylamino)-3-(p-(beta-methoxyethyl)phenoxy)-2-propanol
- (RS)-Metoprolol
- 1-(4-(2-Methoxyethyl)-phenoxy)-3-((1-methylethyl)amino)-2-propanol
- Beatrolol
- Betaloc
- CCRIS 4198
- CGP 2175
- Corvitol
- dl-Metoprolol
- EINECS 257-166-4
- HSDB 6531
- Loresor
- Meijoprolol
- Metohexal
- Metoprolol
- Metoprololum
- Metoprololum [INN-Latin]
- Metrol
- Minax
- Neobloc
- Preblok
- Presolol
- Selo-Zok
- Selokeen
- Seroken
- Spesicor
- Toprol
- UNII-GEB06NHM23
Systematic Names
- 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
- 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-
Registry Numbers
CAS Registry Number
- 51384-51-1
FDA UNII
- GEB06NHM23
Other Registry Numbers
- 37350-58-6
- 54163-88-1
System Generated Number
- 0051384511
Structure Descriptors
InChI
InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3InChIKey
IUBSYMUCCVWXPE-UHFFFAOYSA-NSmiles
COCCc1ccc(OCC(O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 60mg/kg (60mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 186, 1979. | |
| mouse | LD50 | intraperitoneal | > 200mg/kg (200mg/kg) | Farmaco, Edizione Scientifica. Vol. 41, Pg. 80, 1986. | |
| mouse | LD50 | intravenous | 62mg/kg (62mg/kg) | United States Patent Document. Vol. #4252984, | |
| mouse | LD50 | oral | 1050mg/kg (1050mg/kg) | United States Patent Document. Vol. #4252984, | |
| mouse | LD50 | subcutaneous | > 600mg/kg (600mg/kg) | Collection of Czechoslovak Chemical Communications. Vol. 50, Pg. 2289, 1985. | |
| rat | LD50 | intravenous | 71900ug/kg (71.9mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977. | |
| rat | LD50 | oral | 3470mg/kg (3470mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977. | |
| women | TDLo | oral | 17mg/kg/17D-I (17mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS | Annals of Internal Medicine. Vol. 108, Pg. 67, 1988. |
| women | TDLo | oral | 150mg/kg (150mg/kg) | CARDIAC: CHANGE IN FORCE OF CONTRACTION BEHAVIORAL: SLEEP SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Acta Medica Scandinavica. Vol. 218, Pg. 525, 1985. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 1.88 | (none) | EXP | |
| Water Solubility | 1.69E+04 | mg/L | 25 | EXP |
| Vapor Pressure | 2.88E-07 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.40E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.47E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.