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Substance Name: Fludrocortisone acetate [USP:JAN]
RN: 514-36-3
UNII: V47IF0PVH4
InChIKey: SYWHXTATXSMDSB-GSLJADNHSA-N

Classification Codes

  • Adrenocortical Steroid (Salt-Regulating)
  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H31-F-O6

Molecular Weight

  • 422.4899
 

Names and Synonyms

Name of Substance

  • Fludrocortisone acetate
  • Fludrocortisone acetate [USP:JAN]

Synonyms

  • 9-alpha-Fluorohydrocortisone acetate
  • 9-alpha-Fluorohydrocortisone-21-acetate
  • 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
  • 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
  • 9alpha-Fluorohydrocortisone 21-acetate
  • 9alpha-Fluorohydrocortisone acetate
  • Alflorone acetate
  • BRN 2067486
  • Cortef-F
  • Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate
  • Cortineff
  • Cortisol, 9-fluoro-, 21-acetate
  • EINECS 208-180-4
  • F-Cortef acetate
  • Florinef
  • Florinef acetate
  • Fludrocortisone 21-acetate
  • Fludrocortisone acetate
  • Fluohydrocortisone acetate
  • Fluorocortisone acetate
  • NSC 15186
  • Scherofluron
  • U 4845
  • UNII-V47IF0PVH4

Systematic Names

  • Fludrocortisone 21-acetate
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11beta)-
  • Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate
  • Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-, 21-acetate (8CI)

Registry Numbers

CAS Registry Number

  • 514-36-3

FDA UNII

  • V47IF0PVH4

System Generated Number

  • 0000514363

Structure Descriptors

InChI

1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1

InChIKey

SYWHXTATXSMDSB-GSLJADNHSA-N

Smiles

[C@@H]12[C@@]([C@@]3(C(=CC(=O)CC3)CC2)C)([C@H](C[C@]2([C@H]1CC[C@@]2(C(=O)COC(=O)C)O)C)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 240mg/kg (240mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.
rat LD50 oral > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 666, 1987.